2017, Number 2
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Rev Mex Patol Clin Med Lab 2017; 64 (2)
Zika’s destructive passage through the fetus
Romero FR, Benet GCA, Ornelas MLE, Rangel GCM, Romero CR
Language: Spanish
References: 10
Page: 63-65
PDF size: 263.85 Kb.
ABSTRACT
Zika virus (ZIKV) is a
Flavivirus that has become important because of the neurological alterations that it can cause in fetuses. The ZIKV mainly affects the radial glial cells, generating death and lack of cell proliferation, which lead to microcephaly of the fetus in the first trimester of pregnancy. The objective of this work is to describe the known mechanisms through which ZIKV produces abnormalities of the fetal nervous system.
REFERENCES
OMS. Enfermedad por el virus de Zika. Disponible en: http://www.who.int/2016. Recuperado de: http://www.who.int/mediacentre/factsheets/zika/es/.
Behera BMaB. The mysterious Zika virus: adding to the tropical Flavivirus mayhem PMC2016. Recuperado de: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105211/.
OMS. Alerta epidemiológica, síndrome neurológico, anomalías congénitas e infección por virus Zika. Implicaciones para la salud pública en las Américas 2015 [cited 2017]. Disponible en: http://www2.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32404&lang=es.
Calvet G, Aguiar RS, Melo AS, Sampaio SA, de Filippis I, Fabri A et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016; 16 (6): 653-660.
OMS. WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barré syndrome 2016 [cited 2017]. Disponible en: http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/.
Krauer F, Riesen M, Reveiz L, Oladapo OT, Martínez-Vega R, Porgo TV et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: systematic review. PLoS Med. 2017; 14 (1): e1002203.
Olagnier D, Muscolini M, Coyne CB, Diamond MS, Hiscott J. Mechanisms of Zika virus Infection and Neuropathogenesis. DNA Cell Biol. 2016; 35 (8): 367-372.
Miner JJ, Diamond MS. Understanding how Zika virus enters and infects neural target cells. Cell Stem Cell. 2016; 18 (5): 559-560.
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016; 352 (6287): 816-818.
Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe. 2016; 19 (5): 705-712.