medigraphic.com

2013, Number 1

<< Back Next >>

Rev Educ Bioquimica 2013; 32 (1)

El papel de la Galectina-3 en el desarrollo del cancer de mama

Gallegos B, Cuevas B, Pérez CE, Coutiño E, Hernández CP

Language: Spanish
References: 32
Page: 3-12
PDF size: 916.99 Kb.


ABSTRACT

Breast cancer is the second cause of death of women in the world and when it is diagnosed opportunely can be cured. Recently it has been observed that changes in the oligosaccharides structures of membrane proteins are related to the transformation processes and cellular proliferation, in addition, the presence of receptor for these carbohydrates, can potentialise the metastatic capacity of the tumor. In this revision a general overview of the glycosylated markers and their receptors, especially galectin-3 that, has been associated to the breast cancer.


REFERENCES

  1. Bloom HJG, Richardson WW (1957) Histologic grading and prognosis in breast cancer: A study of 1.709 cases of which 359 have been followed for 15 years. Br J Cancer 2:353-377.

  2. Carraway KL, Hull SR (1991) Cell surface mucin-type glycoprotein and mucin like domains. Glycobiology 1:131-138.

  3. Montreuil J (1995) Methods on Glycoconjugates. A Laboratory Manual, Editor: André Verbert. Harwood Academic Publishers. Austria. pp 1-23.

  4. Brockhausen I (2006) Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions. EMBO Rep 7:599-604.

  5. Zhuang D, Yousefi S, Dennis JW (1991) Tn antigen and UDP-Gal:GalNAc alpha-R beta1- 3Galactosyltransferase expression in human breast carcinoma. Cancer Biochem Biophys. 12:185-98.

  6. Cao Y, Karsten U, Otto G, Bannasch P (1999) Expression of MUC1, Thomsen-Friedenreich antigen, Tn, sialosyl-Tn, and alpha2,6-linked sialic acid in hepatocellular carcinomas and preneoplastic hepatocellular lesions. Virchows Arch 434:503-9.

  7. Van den Steen P, Rudd MP, Dwek AR, Opdenaker G (1998) Concepts and Principles of O-glycosylation. Crit Rev Biochem Mol Biol 33:151-208.

  8. Kawaguchi T, Takazawa H, Imai S, Morimoto J, Watanabe T, Kanno M, Igarashi S (2006) Expression of Vicia villosa agglutinin (VVA)- binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA? Breast Cancer Res Treat 98:31-43.

  9. Brooks S A, Hall D M, Buley I (2001) GalNAc glycoprotein expression by breast cell lines, primary breast cancer and normal breast epithelial membrane. Br J Cancer 28:1014-22.

  10. Stanley M W, Kiang D T, Sibley RK (1986). Peanut lectin binding in breast carcinoma. Lack of correlation with estrogen receptor content. Cancer Nov 1;58(9):2046-51.

  11. Santaella A, Gallegos B, Perez E, Zenteno E, Hernández P (2007) Use of Amaranthus leucocarpus Lectin to Differentiate Cervical Dysplasia (CIN) Prep Biochem Biotechnol 37:219-228.

  12. Gallegos B, Pérez-Campos E, Martinez R, Leyva P, Martinez M, Hernández R, Pina S, Hernández C, Zenteno E, Hernández P (2010) O-glycosilation expression in fibroadenoma. Prep Biochem Biotechnol 40:1-12.

  13. Rabinovich GA (1999) Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy. Cell Death Differ 6:711-22.

  14. Kasai K, Hirabayashi J (1996) Galectins: a family of animal lectins that decipher glycocodes. J Biochem 119:1-8.

  15. Yoshimasa I (2000) Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties. Eur J Biochem 267:2955-64.

  16. Dagher SF, Wang JL, Patterson RJ (1995) Identification of galectin-3 as a factor in pre-mRNA splicing. Proc Natl Acad Sci USA 92:1213-7.

  17. Gillenwater A, Xu XC, Estrov Y, Sacks PG, Lotan D, Lotan R (1998) Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. Int J Cancer 75:217-24.

  18. Leffler H (1997) Introduction to galectins. Trends Glycosci. Glycotechnol 9:9–19.

  19. Moutsatsos IK, Davis JM, Wang J (1986) L. Endogenous lectins from cultured cells: subcellular localization of carbohydratebinding protein 35 in 3T3 fibroblasts. Journal of Cell Biology 102:477–483.

  20. Krzeslak A, Lipinska A (2004) Galectin-3 as a multifunctional protein. Cell Mol Biol Lett 9:305-328.

  21. Brewer CF (1997) Cross-linking activities of galectins and other multivalent lectins. Trends Glycotech 9:155-165.

  22. Lin HM, Pestell RG, Raz A, Kim HRC (2002) Galectin-3 enhances cyclin D(1) promoter activity through SP1 and Camp-responsive element in human breast epithelial cells. Oncogen 21:8001-8010

  23. Yang R, Hsu D, Liu T (1996) Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci USA 93:6737– 6742.

  24. Roland J Pieters (2006) Inhibition and Detection of Galectins. ChemBioChem 7:721– 728.

  25. Lu-Gang Yu, Nigel Andrews, Qicheng Zhao, Daniel McKean, Jennifer F. Williams, Lucy J. Connor, Oleg V. Gerasimenko, John Hilkens Jun Hirabayashi, Kenichi Kasai, Jonathan M. Rhodes (2007) Galectin-3 Interaction with Thomsen-Friedenreich Disaccharide on Cancer-associated MUC1 Causes Increased Cancer Cell Endothelial Adhesion Journal of Biological Chemistry 282:773-781.

  26. Honjo Y, Nangia-Makker P, Inohara H, Ra A (2001) Downregulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells. Clin Cancer Res 7:661–668.

  27. Liu FT, Rabinovich GA (2005) Galectins as modulators of tumour progression. Nat Rev Cancer 5:29-41.

  28. Honjo Y, Nangia-Makker P, Inohara H, Raz A (2001) Down-regulation of galectin-3 suppresses tumorigenecity of human breast carcinoma cells. Clin Cancer Res 7:661–668.

  29. Song YK, Billiar TR, Lee YJ (2002) Role of galectin- 3 in breast cancer metastasis. Involvement of nitric oxide. Am J Pathol 160:1069– 1075.

  30. Mayoral MA, Mayoral C, Meneses A, Villalvazo L, Guzman A, Espinosa B, Ochoa JL, Zenteno E, Guevara J (2007) Identification of Mucin-type O-glycans and Galectin-3 in breast cancer and brain metastasis. Cancer Invest 26:615-23.

  31. K. Sujathan1, Thara Somanathan1, Nimi GK, Preethi Sara George, Elizabeth K. Abraham y P. Remani. (2011) Down regulation of galectin- 3 in primary tumor tissues of breast predict axillary lymph node metastasis. Journal of Cancer Research and Experimental Oncology Vol. 3:37-49.

  32. Iurisci I, Tinari N, Natoli C, Angelucci D, Cianchetti E, Iacobelli S (2000) Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res 6:1389- 1393.




2020     |     www.medigraphic.com