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2017, Number 5

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Acta Pediatr Mex 2017; 38 (5)

Post-infectious bronchiolitis obliterans: characteristics and follow up of 21 cases in Bogotá-Colombia at 2640 m above sea level

Ucrós-Rodríguez S, Quiroga-Durán SP, Díaz-Martínez M, Méndez-García AP, Pérez-Azuero A

Language: Spanish
References: 18
Page: 308-316
PDF size: 789.95 Kb.


ABSTRACT

Background: Post-infectious bronchiolitis obliterans (PIBO) is a childhood chronic pulmonary disease, sequelae of an acute bronchiolitis during the first months of life. PIBO has been reported at low altitudes and at sea level but there are not follow up reports from altitudes higher than 2,500 m. The aim of this research was the description of the main features and prognosis of children with PIBO in Bogotá-Colombia at 2,640 m above sea level.
Methods: PIBO cases were derived from a paediatric pulmonology reference clinic. Diagnosis was made according to the medical literature recommendations. The study was carried out from January 2015 to June 2016 and had both a retrospective component and a prospective one.
Results: We found 21 PIBO cases. The mean follow up time was 5.6 years and the mean age for the initial event was 6.7 months; 76% of the patients were male and 76% required mechanical ventilation in the initial episode. The evolution was from medium to poor in 71% of the cases; 33% patients had bronchiectasis and 43% had pulmonary hypertension in their first evaluation.
Conclusions: This is the first PIBO follow up study published from altitudes above 2,500 m. The main factors associated with PIBO developing and the disease prognosis are in accordance with descriptions at low altitude and sea level.


REFERENCES

  1. Castro-Rodriguez JA, Giubergia V Fischer GB, et al. Postinfectious bronchiolitis obliterans in children: The South American contribution. Acta Paediatr. 2014;103(9):913-21.

  2. Lino CA, Batista AK, Soares MA, de Freitas AE, Gomes LC, M Filho JH, Gomes VC. Bronquiolitis obliterans: clinical and radiological profile of children follow-up in a reference outpatient clinic. Rev Paul Pediatri. 2013;31:10-16.

  3. Champs NS, Lasmar LM, Camargos PA, Marguet C, Fischer GB, Mocelin HT. Post-infectious bronchiolitis obliterans in children. Journal de Pediatría (Rio J). 2011;87:187-198.

  4. Zhang L, Camargo JJ, Irion K, da Silva Porto N, Kozakewich H, Reid L, and Abreu e Silva F. Clinical Course of Postinfectious Bronchiolitis Obliterans. Pediatr Pulmonol. 2000;29:341–350.

  5. Mattiello R, Mallol J, Fischer GB, Mocelin HT, Rueda B, Sarria EE. Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans. J Bras Pneumol. 2010;360:453-9.

  6. Aguerre V, Castaños C, Pena HG, Grenoville M, Murtagh P. Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. Pediatric Pulmonology. 2010;45:1180–1185.

  7. Azizi Haji O, Manan A, Bronchiolitis obliterans in children –A report of six cases. Med J Malasya. 1989;44:204-209.

  8. Chih-Yung Chiu, Kin-Sun Wong, Yhu-Chering Huang and Tzou-Yien Lin. Bronquiolitis obliterans in children: Clinical presentation, therapy and long-term follow-up. Journal of Paediatrics and Child Health. 2008;44:129-133.

  9. Yüksel H, Yilmaz O, Urk V, Yüksel D, Göktan C, Savaş R, Sayit E. Clinical significance of lung perfusion defects in children with post-infectious bronchiolitis obliterans. Tuberk Toraks. 2009;57:376-82.

  10. Sardón O, Pérez-Yarza EG, Aldasoro A, Corcuera P, Mintegui J, Korta J. Bronquiolitis obliterante. Evolución a medioplazo. An Pediatr (Barc). 2012;76:58-64.

  11. Cazzato S1, Poletti V, Bernardi F, Loroni L, Bertelli L, Colonna S, Zappulla F, Timoncini G, Cicognani A. Airway inflammation and lung function decline in childhood post-infectious bronchiolitis obliterans. Pediatr Pulmonol. 2008;43:381–390.

  12. Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CPM, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF and Wanger J. Series ‘‘ATS/ERS task force: standardisation of lung function testing.’’ Interpretative strategies for lung function tests. Eur Respir J. 2005;26:948–968.

  13. Pang YL, Ma RY, Qi HY, Sun K. Comparative study of the indexes of pulmonary arterial pressure of healthy children at different altitudes by Doppler echocardiography. Chinese Journal of Pediatrics. 2004;42:595-599.

  14. Panqueva O, Jiménez JC. Bronquiolitis obliterante en Pediatría. Revista Colombiana de Neumología. 2012;24:41-44.

  15. Lang WR, Howden CW, Laws J, Burton JF.Bronchopneumonia with serious sequelae in children with evidence of adenovirus type 21 infection.Br Med J 1969;1:73-9.

  16. Alharbi S, Van Caeseele P, Consunji-Araneta R, Zoubeidi T, Fanella S, Souid AK, Alsuwaidi AR. Epidemiology of severe pediatric adenovirus lower respiratory tract infections in Manitoba, Canada, 1991-2005. BMC Infect Dis. 2012;12:55. doi: 10.1186/1471-2334-12-55.

  17. Colom AJ, Maffey A, Garcia Bournissen F, Teper A. Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up. Thorax 2015;70:169-74.

  18. Díaz GF, Márquez A. Hipertensión pulmonar a moderada altura. En: Hipertensión pulmonar en niños. Ed. Distribuna Colombia 2011. pp. 295-313.




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