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Colegio de Medicina Interna de México.

2017, Number 3

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Med Int Mex 2017; 33 (3)

Systemic immune inflammatory index in sepsis.

Lagunas-Alvarado M, Mijangos-Huesca FJ, Terán-González JO, Lagunas-Alvarado MG, Martínez-Zavala N, Reyes-Franco I, Hernández-Mendiola R, Santillán-Fragoso WJ, Copca-Nieto DV, López y López LR, Ramírez-Del Pilar R, López-González DS, Vázquez-Arteaga S, Reyes-Jiménez AE, Alba-Rangel DL

Language: Spanish
References: 33
Page: 303-309
PDF size: 375.82 Kb.


ABSTRACT

Background: In the past several indices based on peripheral blood cells have been studied to prove their utility as prognostic factors in endothelial dysfunction, cardiovascular risk and mortality. In 2014 the systemic immune inflammatory index (SII) was developed and it has been proposed as a prognostic factor in the follow-up of patients with cancer.
Objetive: To determine if there is a modification of the SII in patients with sepsis.
Material and Method: A retrospective study included randomized patients hospitalized from 2013 to 2015; homogeneity of populations was verified by demonstrating that there was no statistical difference between age and comorbidities (Kolmogorov-Smirnov distribution), frequency of comorbidities (χ2). IIS was calculated with the blood cell count on hospital admission. IIS was compared in sepsis and without sepsis patients (Wilcoxon), and we determined whether there was correlation between IIS and sepsis (correlation coefficient biserial point).
Results: There were included 242 patients (128 with sepsis, mean age 70.1 years and 114 without sepsis, mean age 69.7 years). The mean IIS in patients with sepsis was 4444.06×109 and without sepsis 3013.94×109. We showed that there was statistically significant correlation between IIS and sepsis (rbp=0.150253625, p=0.05), we also detailed that the mean IIS was significantly higher in patients with sepsis (W=5,097, p=0.00001).
Conclusion: The IIS, an innovative index that has shown accuracy describing the imbalance of immunity and inflammation, is proposed as a tool that can be useful in patients with sepsis; however, further studies are required to prove its potential in prognosis and monitoring.


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