2017, Number 1
<< Back
AbanicoVet 2017; 7 (1)
Diagnosis and treatment of mellitus diabetes in dogs
Álvarez-Linares B, Ávila-Ramos F, López-Briones S
Language: Spanish
References: 31
Page: 53-67
PDF size: 281.54 Kb.
ABSTRACT
Diabetes mellitus (DM) is a metabolic disease that often occurs in dogs. This is characterized by hyperglycemia in plasma. To date, it has not been developed a classification of different types of this disease in dogs, such as in humans. In humans, it can be classified as type I and type II DM, as well as gestational DM. In dogs, the same classification is used, but usually, there are some clinical symptoms of DM associated with diestrus and pancreatitis. 50% DM type I is diagnosed in dogs and less frequent type II DM and other. The main clinical signs in dogs are polyuria, polydipsia, weight loss, polyphagia and less common hepatomegaly and cataracts. For Laboratory diagnosis three tests are usually applied: blood count, biochemical profile and urinalysis. When positive results of hyperglycemia and glycosuria are found, the patient will be diagnosed with DM and veterinarian will provide an adequate treatment based on insulin therapy, balanced diet, and regular exercise. Therefore, the aim of this review is to provide basic and update information about DM for public, veterinary students, and veterinarians.
REFERENCES
American Diabetes Association (ADA). (2013). Standards of medical care in diabetes Diabetes Care. 36(1):11-66. http://dx.doi.org/10.2337/dc13-S011.
APTEKMANN KP, Armstrong J, Coradini M, Rand J. (2014). Owner experiences in treating dogs and cats diagnosed with diabetes mellitus in the United States. Journal of the American Animal Hospital Association. 50(4):247-53. doi: 10.5326/JAAHA-MS-6101.
ASIF M. (2005). The prevention and control the type-2 diabetes by changing lifestyle and dietary pattern. Journal of Education and Health Promotion. 2014. 3: 1. doi: 10.4103/2277-9531.127541.
CATCHPOLE B, Ristic JM, Fleeman LM, Davison LJ.(2005). Canine diabetes mellitus: can old dogs teach us new tricks?. Diabetologia. 48(10):1948-56. doi: 10.1007/s00125-005-1921-1.
COOK AK. (2012). Monitoring methods for dogs and cats with diabetes mellitus. Journal of Diabetes Science and Technology. 6(3): 491-495. http://jdst.org/May2012/PDF/ Abstracts/VOL-6-3-SYM1-COOK-ABSTRACT.pdf
DAVISON LJa, Walding B, Herrtage ME, Catchpole B. (2008) . Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. Journal of Veterinary Internal Medicine. 22(6):1317-25. doi: 10.1111/j.1939-1676.2008.0194.
DAVISON LJb, Weenink SM, Christie MR, Herrtage ME, Catchpole B. (2008). Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Veterinary Immunology and Immunopathology. 126(1-2): 83-90. doi: 10.1016/j.vetimm.2008.06.016.
DAVISON LJ, Herrtage ME, Catchpole B. (2011). Autoantibodies to recombinant canine proinsulin in canine diabetic patients. Research in Veterinary Science. 91(1):58-63. doi.org/10.1016/j.rvsc.2010.08.007.
DIFAZIO J, Fletcher DJ. (2016). Retrospective comparison of early- versus late-insulin therapy regarding effect on time to resolution of diabetic ketosis and ketoacidosis in dogs and cats: 60 cases (2003-2013). Journal of Veterinary Emergency and Critical Care. 26(1):108-15. doi: 10.1111/vec.12415.
DONZEL E, Arti L, Chahory S. (2016). Epidemiology and clinical presentation of canine cataracts in France: a retrospective study of 404 cases. Veterinary Ophthalmol. 1-9. doi: 10.1111/vop.12380.
FALL T, Johansson KS, Juberget A, Bergström A, Hedhammar A. (2008). Gestational diabetes mellitus in 13 dogs. Journal of Veterinary Internal Medicine. 22(6):1296-300. doi: 10.1111/j.1939-1676.2008.0199.x.
FLEEMAN LM, Rand JS. (2003). Evaluation of day-to-day variability of serial blood glucose concentration curves in diabetic dogs. Journal of the American Veterinary Medical Association. 222(3): 317-21. doi: 10.2460/javma.2003.222.317.
GILOR C, Niessen SJ, Furrow E, DiBartola SP. (2016). What's in a Name? Classification of diabetes mellitus in veterinary medicine and why it matters. Journal of Veterinary Internal Medicine. 30(4):927-40. doi: 10.1111/jvim.14357.
GUPTILL L, Glickman L, Glickman N. (2003). Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970-1999). The Veterinary Journal. 165(3):240-247. doi: 10.1016/S1090-0233(02)00242-3.
HARDY RM. (1988). Diabetes mellitus en el perro y en el gato. Revista de AVEPA. 8(2): 71-88. https://ddd.uab.cat/pub/clivetpeqani/11307064v8n2/11307064v8n2p71.pdf
HESS RS, Ward CR. (2000). Effect of insulin dosage on glycemic response in dogs with diabetes mellitus: 221 cases (1993-1998). Journal of the American Veterinary Medical Association. 216(2):217-21. doi: 10.2460/javma.2000.216.217.
KENNEDY LJ, Davison LJ, Barnes A, Short AD, Fretwell N, Jones CA, Lee AC, Ollier WER, Catchpole B. (2006). Identification of susceptibility and protective major histocompatibility complex haplotypes in canine diabetes mellitus. Tissue Antigens. 68(6):467-476. doi: 10.1111/j.1399-0039.2006.00716.x.
KIMMEL SE, Michel KE, Hess RS, Ward CR. (2000). Effects of insoluble and soluble dietary fiber on glycemic control in dogs with naturally occurring insulin-dependent diabetes mellitus. Journal of the American Veterinary Medical Association. 216(7):1076-81. doi: 10.2460/javma.2000.216.1076.
LOSTE A, Marca, MC. (2001). Fructosamine and glycated hemoglobin in the assessment of glycaemic control in dogs. Veterinary Research. 32(1):55-62. doi: 10.1051/vetres:2001109.
MARCA MC, Loste A, Unzueta A, Pérez M. (2000). Blood glycated hemoglobin evaluation in sick dogs. The Canadian Journal Veterinary Research. 64(2):141-144.
MARED M, Catchpole B, kämpe O, Fall T. (2012). Evaluation of circulating concentrations of glucose homeostasis biomarkers, progesterone, and growth hormone in healthy Elkhounds during anestrus and diestrus. American Journal of Veterinary Research. 73(2): 242-247. doi: 10.2460/ajvr.73.2.242.
MICELI DD, Gallelli MF, Cabrera BMF, Martiarena B, Brańas MM, Ortemberg LR, Gómez NV, Castillo VA. (2012). Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism. Research in Veterinary Science. 93(1): 114-20.
NELSON RW, Reusch CE. (2014). Animal models of disease: classification and etiology of diabetes in dogs and cats. Journal Endocrinology. 222(3):T1-9. doi: 10.1530/JOE-14-0202.
O'BRIEN MA. (2010). Diabetic emergencies in small animals. Veterinary Clinics of North America: Small Animal Practice. 40(2):317-333. doi.org/10.1016/j.cvsm.2016. 10.010.
O'NEILL S, Drobatz K, Satyaraj E, Hess R. (2012). Evaluation of cytokines and hormones in dogs before and after treatment of diabetic ketoacidosis and in uncomplicated diabetes mellitus. Veterinary Immunology and Immunopathology. 148(3-4):276-83. doi: 10.1016/j.vetimm. 2012.06.027.
OSTO M, Lutz TA. (2015). Translational value of animal models of obesity-Focus on dogs and cats. European Journal Pharmacology. 759:240-52. doi: 10.1016/j.ejphar. 2015.03. 036.
SAKO T, Mori A, Lee P, Goto H, Fukuta H, Oda H, Saeki K, Miki Y, Makino Y, Ishioka K, Mizutani H, Kojima Y, Koikeda S, Arai T. (2010). Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs. Veterinary Research Communications. 34(2): 161-72. doi: 10.1007/s11259-010-9342-0.
SWITONSKI M. (2014). Dog as a model in studies on human hereditary diseases and their gene therapy. Reproductive Biology. 14(1): 44-50. doi: 10.1016/j.repbio.2013.12.007.
VERKEST KR, Rand JS, Fleeman LM, Morton JM. (2012). Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs. Domestic Animal Endocrinology. 42(2):103-112. doi: 10.1016/j.domaniend. 2011.10.002.
WALSH ES, Drobatz KJ, Hess RS. (2016). Use of intravenous insulin aspart for treatment of naturally occurring diabetic ketoacidosis in dogs. Journal of Veterinary Emergency and Critical Care. 26(1):101-107. doi: 10.1111/vec.12375.
WILKIE DA, Gemensky-Metzler AJ, Colitz CHM, Bras ID, Kuonen VJ, Norris KN, Basham CR. (2006). Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18 dogs. Veterinary Ophthalmology. 9(5):328-34. doi: 10.1111/j.1463-5224.2006.00490.