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Federación Mexicana de Ginecología y Obstetricia, A.C.

2016, Number 07

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Ginecol Obstet Mex 2016; 84 (07)

Premature Labor. Efficacy and safety of three different therapy regimens

de la Luna-y Olsen E, Carranza- Sánchez B, Vences-Avilés MA

Language: Spanish
References: 40
Page: 440-448
PDF size: 345.88 Kb.


ABSTRACT

Objetive: To asses the results of three different drugs in the treatment of acute premature labor within the first 48 hours and after 7 days of the event, in order to determine which of them provides better results with the least number of complications.
Methods: Longitudinal, prospective study in three groups of patients between 24 to 34 weeks of pregnancy. The first group, with indomethacin; the second group, with salbutamol, and the third group with atosiban. Statistical analysis of the three groups to compare success/ failure rates within the first 48 hours, inhibition of uterine contractility after seven days, and side effects during the accute stage of uterine inhibition. The same data was analyzed in all three groups. All patients in the three groups received a betamethsone régimen to induce fetal lung maturity.
Results: The indomethacine group, with 656 patients, showed uterine inhibition success within 48 hours in 582 patients, failure in 74 patients, uterine inhibition after seven days in 429 patients, and side effects in 174 patients. The salbutamol group, with 776 pacients, showed uterine inhibition success within 48 hours in 658 patients, failure in 118 patients, uterine inhibition after seven days in 564 patients, and side effects in 302 patients. The atosiban group, with 82 pacients, showed uterine inhibition success within 48 hours in 75 patients, failure in 7 patients, uterine inhibition after seven days in 69 patients, and side effects in 4 patients.
Conclusions: The results for accute fase inhibition of uterine contractility were similar for the three drugs, while uterine contractility inhibition after seven days and side effects showed an improvement in the group treated with atosiban (p=0.001).


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