medigraphic.com

2017, Number 3

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2017; 55 (3)

Early neonatal sepsis and associated factors

Anaya-Prado R, Valero-Padilla C, Sarralde-Delgado A, Sánchez-González JM, Montes-Velázquez L, Gil-Villarreal F

Language: Spanish
References: 25
Page: 317-323
PDF size: 323.50 Kb.


ABSTRACT

Background: Early-onset neonatal sepsis (EONS) is an infectious disease of low incidence but high morbidity and mortality with severe consequences to the newborn prognosis. Identifying the associated factors related to EONS allows to start a timely treatment and to take preventive measures.
Methods: In this case and controls study we identified all the newborns (NB) with and without EONS (cases and controls), diagnosed through blood culture in a period of three years. We studied risk factors such as: low gestational age, gender, weight, maternal infections, and premature rupture of membranes.
Results: Our study consisted of 27 cases and 36 controls, with a mean age of 32.43 and 33.19 weeks of gestation (WOG), respectively (p › 0.05). Of these, 22 and 29 of the cases and controls had a gestational age ‹ 37 WOG, (p › 0.05). However, maternal infection (odds ratio [OR] 1.76), respiratory distress syndrome (OR 4.72), the need of resuscitation (OR 2.9), intubation (OR 5.1) and ventilation support (OR 2.6) were statistically different between both groups (p ‹ 0.05). The most isolated microorganism was Staphylococcus coagulase negative (42.3%).
Conclusion: Risk factors associated with EONS were maternal infection, the need of resuscitation, and intubation to ventilation support.


REFERENCES

  1. Mukhopadhyay S, Puopolo KM. Risk Assessment in Neonatal Early-Onset Sepsis. Semin Perinatol. 2012;36(6):408-15.

  2. Satar M, Özlü F. Neonatal sepsis: a continuing disease burden. Turk J Pediatr. 2012 Sep-Oct;54(5):449-57.

  3. Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community- based studies. Pediatr Infect Dis J. 2009;28 (Suppl 1):S3-9.

  4. Rodríguez-Weber MA, López-Candiani C, Arredondo- García JL, Gutiérrez-Castrellón P, Sánchez- Arriaga F. Morbilidad y mortalidad por sepsis neonatal en un hospital de tercer nivel de atención. Salud Publica Mex. 2003;45(2):90-5.

  5. Segura CE, Arredondo GJL. Sepsis neonatal. En: Arredondo JL, Figueroa DR (eds.). Temas actuales en infectología. México DF: Intersistemas; 2000. pp. 323-335.

  6. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014 Jan;27(1):21-47. doi: 10.1128/CMR.00031-13.

  7. Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med. 2008;9(2):186-91.

  8. Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al. Early onset neonatal sepsis: the burden of Group B Streptococcal and E. coli continues. Pediatrics. 2011;127(5):817-26.

  9. Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of Invasive Group B Streptococcal Disease in the United States, 1999-2005. JAMA. 2008;299(17):2056-65.

  10. Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011;128(5):e1155-63.

  11. Weston EY, Pondo T, Lewis MM, Martell-Cleary P, Morin C, Jewell B, et al. The Burden of Invasive Early-onset Neonatal Sepsis in the United States, 2005–2008. Pediatr Infect Dis J. 2011;30(11):937-41.

  12. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126(3):443-56.

  13. Cortese F, Scicchitano P, Gesualdo M, Filaninno A, De Giorgi E, Schettini F, et al. Early and Late Infections in Newborns: Where Do We Stand? A Review. Pediatr Neonatol. 2016 Aug;57(4):265-73.

  14. Huang FK, Chen HL, Yang PH, Lin HC. Bird’s Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection. Pediatr Neonatol. 2016; 57(3):167-73.

  15. Karthikeyan G, Premkumar K. Neonatal sepsis: Staphylococcus aureus as the predominant pathogen. Indian J Pediatr. 2006;68(8):715-7.

  16. Wynn J, Cornell TT, Wong HR, Shanley TP, Wheeler DS. The host response to sepsis and developmental impact. Pediatrics. 2010;125(5):1031-41.

  17. Heath PT. Status of vaccine research and development of vaccines for GBS. Vaccine. 2016 Jun 3;34 (26):2876-9. doi: 10.1016/j.vaccine.2015.12.072.

  18. Patiño-Cossio N. Sepsis neonatal. Rev Soc Bol Ped. 2007;46(3):225-33.

  19. Anaya-Prado R, Madrigal-Flores S. Reveles-Vázquez JA, Ramírez-Barba EJ, Frías-Terrones G, Godínez-Rubí JM. Morbilidad Materna Asociada a Operación Cesárea. Cir Cir. 2008;76(6):467-72.

  20. Van Dyke MK, Phares CR, Lynfield R, Thomas AR, Arnold KE, Craig AS. Evaluation of Universal Antenatal Screening for Group B Streptococcus. N Engl J Med. 2009;360:2626-36.

  21. Reid KC, Cockerill III FR, Patel R. Clinical and Epidemiological Features of Enterococcus casseliflavus/ flavescens and Enterococcus gallinarum Bacteremia: A Report of 20 Cases. Clin Infect Dis. 2001 Jun 1;32(11):1540-6.

  22. Chang-Hua Ch, Chieh-Chen H. Risk factor analysis for extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections in central Taiwan. BMC Infect Dis. 2013 Sep 8;13:417.

  23. Blinkhorn R J, Adelstein D, Spagnuolo PJ. Emergence of a New Opportunistic Pathogen, Candida lusitaniae. J Clin Microbiol. 1989;27(2):236-40.

  24. Purty S, Saranathan R, Narayanan PK, Asir J, Devi CS, Amarnath SK. The expanding spectrum of human infections caused by Kocuria species: a case report and literature review. Emerg Microbes Infect. 2013 Oct;2(10):e71.

  25. Aguado-Urda M, López-Campos GH, Blanco MM, Fernández-Garayzábal JF, Cutuli MT, Aspiroz C, et al. Genome Sequence of Lactococcus garvieae 21881, Isolated in a Case of Human Septicemia. J Bacteriol. 2011;193(15):4033-4.




2020     |     www.medigraphic.com