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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2017, Number 2

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An Med Asoc Med Hosp ABC 2017; 62 (2)

Recurrent fungal allergic rhinosinusitis in an immune therapy treated case series

Hernández CLE, Yáńez GC, Pirrón LJA

Language: Spanish
References: 21
Page: 95-99
PDF size: 209.08 Kb.


ABSTRACT

Background: Fungal allergic rhinosinusitis requires surgery; the postoperative treatment varies, and 10 to 100% of the cases recur. Patients have hypersensitivity to multiple fungal allergens, so postsurgical immunotherapy could reduce the rate of recurrences. Objective: To identify the frequency of post-surgical recurrence of fungal allergic rhinosinusitis in patients receiving immunotherapy. Methods: Non-experimental, ambispective, longitudinal case series in patients with allergic fungal rhinosinusitis treated with paranasal sinus endoscopic surgery. Specific immunotherapy started one month after surgery and continued along three years. The study variable was the recurrence of thickening of the sinus mucosa; its prevalence and 95% confidence intervals were identified. Results: Eleven patients participated, their mean age was 33.7 ± 6.4 years, eight were males (72.7%); the most frequent fungal allergens were Alternaria, Penicilium, Rhizopus and Mucor (72.7% each). Two patients had a recurrence (18.2%, 95% C.I. 0.0-41.0%), one had an anatomical variant. Cladosporium allergy had a trend towards being more frequent in patients with recurrence (100%) than in patients without it (11.1%, p = 0.05). Conclusion: Postsurgical recurrence of fungal allergic rhinosinusitis presented in 18.2% of patients treated with immunotherapy; confidence intervals show that it could be less frequent than previously reported.


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