Zumaquero-Ríos JL, Pérez-Santos M, Villa-Mancera A, Sarracent-Pérez J

Language: Spanish
References: 20
Page: 24-30
PDF size: 114.62 Kb.

ABSTRACT

Different approaches to vaccination against T. spiralis using murine experimental models have been used, but the levels of protection observed in most experimental trials may not be sufficient to provide a good disease control. There is increasing evidence that inhibitors molecules on T cells are critically involved in the regulation of immune response against helminths infections, thus negative stimulators represent possible drug targets since their blockade leads to an increased immune response. Moreover, it has been reported that immunization with excretory-secretory products of T. spiralis muscular larvae could provide partial protective immunity against parasite infection. T. spiralis induce a population of cells with elevated levels of known markers of T regulatory, manipulation of which influences the immune response and parasite load. In the present work we found that immunization with muscle larvae excretory secretory products of T. spiralis and blockade of CTLA-4 displayed remarkable high reduction of muscle larvae burdens in a murine model, showing that elimination of suppressive regulatory pathways results in a more potent and protective The response which reduces muscle larval establishment.

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