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2017, Number 2

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Gac Med Mex 2017; 153 (2)

Hemoglobin changes (Hb) in miners exposed to high altitude and associated factors

Mejia CR, Quiñones-Laveriano DM, Gomero R, Pérez-Pérez L

Language: Spanish
References: 31
Page: 166-172
PDF size: 91.78 Kb.


ABSTRACT

Aim: To determine the variation of hemoglobin (Hb) in two groups of miners working at different altitudes. Methodology: A longitudinal study conducted in a private company. Hb was obtained from entrance exams and annual checks of workers at two locations: at sea level and at Peruvian highlands (4,100 m), taken by trained staff and equipment calibrated to environmental conditions. We analyzed variations in the course of the years with the PA-GEE statistical test; p values were obtained. Results: Of the 376 workers, 89% (322) were men, the median age was 32 years (range 20-57) and 84% (304) were at high altitude. In multivariate analysis, male sex (p ‹ 0.001), body mass index (BMI; p = 0.021) and working at high altitude (p ‹ 0.001) were associated with the greatest variation of Hb in time, adjusted for age, length, and type of work. Discussion: These findings should be considered for health surveillance of workers exposed to similar conditions to prevent chronic mountain sickness. Conclusion: The change in Hb of miners was associated with male sex, BMI, and work at high altitude.


REFERENCES

  1. West JB. High-altitude medicine. Am J Respir Crit Care Med. 2012;186:1229-37.

  2. Bebbington AJ, Bury JT. Minería, instituciones y sostenibilidad: desencuentros y desafíos. Anthropologica. 2012;28:53-84.

  3. Scheinfeldt LB, Tishkoff SA. Living the high life: high-altitude adaptation. Genome Biol. 2010;11:133.

  4. Vearrier D, Greenberg MI. Occupational health of miners at altitude: adverse health effects, toxic exposures, pre-placement screening, acclimatization, and worker surveillance. Clin Toxicol (Phila). 2011;49:629-40.

  5. Ospina E, Bautista R, Vigil L, Diaz J. [Goals of occupational health and environmental protection at the beginning of the 21st century in Peru]. Rev Peru Med Exp Salud Pública. 2012;29:277-9.

  6. Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 2013;27:41-53.

  7. Neya M, Enoki T, Ohiwa N, Kawahara T, Gore CJ. Increased hemoglobin mass and VO2max with 10 h nightly simulated altitude at 3000 m. Int J Sports Physiol Perform. 2013;8:366-72.

  8. Garvican L, Martin D, Quod M, Stephens B, Sassi A, Gore C. Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists. Scand J Med Sci Sports. 2012;22:95-103.

  9. Clark SA, Quod MJ, Clark MA, Martin DT, Saunders PU, Gore CJ. Time course of haemoglobin mass during 21 days live high: train low simulated altitude. Eur J Appl Physiol. 2009;106:399-406.

  10. Brothers MD, Doan BK, Zupan MF, Wile AL, Wilber RL, Byrnes WC. Hematological and physiological adaptations following 46 weeks of moderate altitude residence. High Alt Med Biol. 2010;11:199-208.

  11. León-Velarde F, Monge CC, Vidal A, Carcagno M, Criscuolo M, Bozzini CE. Serum immunoreactive erythropoietin in high altitude natives with and without excessive erythrocytosis. Exp Hematol. 1991;19:257-60.

  12. Al-Sweedan SA, Alhaj M. The effect of low altitude on blood count parameters. Hematol Oncol Stem Cell Ther. 2012;5:158-61.

  13. Data PG, Cacchio M, Monge C, Di Tano G. [Evaluation of various hematologic parameters in Andean miners (Morococha-Peru 4560 m)]. Boll Della Soc Ital Biol Sper. 1981;57:1411-6.

  14. Richalet J-P, Donoso MV, Jiménez D, et al. Chilean miners commuting from sea level to 4500 m: a prospective study. High Alt Med Biol. 2002;3:159-66.

  15. Gunga HC, Röcker L, Behn C, et al. Shift working in the Chilean Andes (> 3,600 m) and its influence on erythropoietin and the low-pressure system. J Appl Physiol (1985). 1996;81:846-52.

  16. Brothers MD, Wilber RL, Byrnes WC. Physical fitness and hematological changes during acclimatization to moderate altitude: a retrospective study. High Alt Med Biol. 2007;8:213-24.

  17. Heinicke K, Prommer N, Cajigal J, Viola T, Behn C, Schmidt W. Longterm exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man. Eur J Appl Physiol. 2003;88:535-43.

  18. Wachsmuth NB, Völzke C, Prommer N, et al. The effects of classic altitude training on hemoglobin mass in swimmers. Eur J Appl Physiol. 2013;113:1199-211.

  19. Gough CE, Saunders PU, Fowlie J, et al. Influence of altitude training modality on performance and total haemoglobin mass in elite swimmers. Eur J Appl Physiol. 2012;112:3275-85.

  20. Tannheimer M, Fusch C, Böning D, Thomas A, Engelhardt M, Schmidt R. Changes of hematocrit and hemoglobin concentration in the cold Himalayan environment in dependence on total body fluid. Sleep Breath Schlaf Atm. 2010;14:193-9.

  21. León-Velarde F, Gamboa A, Chuquiza JA, Esteba WA, Rivera-Chira M, Monge CC. Hematological parameters in high altitude residents living at 4,355, 4,660, and 5,500 meters above sea level. High Alt Med Biol. 2000;1:97-104.

  22. Wu T, Wang X, Wei C, et al. Hemoglobin levels in Qinghai-Tibet: different effects of gender for Tibetans vs. Han. J Appl Physiol (1985). 2005;98:598-604.

  23. Richalet JP, Souberbielle JC, Antezana AM, et al. Control of erythropoiesis in humans during prolonged exposure to the altitude of 6,542 m. Am J Physiol. 1994;266:R756-64.

  24. Cook JD, Boy E, Flowers C, Daroca M del C. The influence of high-altitude living on body iron. Blood. 2005;106:1441-6.

  25. Peng Q, Basang Z, Cui C, et al. Physiological responses and evaluation of effects of BMI, smoking and drinking in high altitude acclimatization: a cohort study in Chinese Han young males. PLoS ONE. 2013;8:e79346.

  26. Pereira-Victorio CJ, Huamanquispe-Quintana J, Castelo-Tamayo LE. Gasometría arterial en adultos clínicamente sanos a 3350 metros de altitud. Rev Peru Med Exp Salud Publica. 2014;31:473-9.

  27. Ri-Li G, Chase PJ, Witkowski S, et al. Obesity: associations with acute mountain sickness. Ann Intern Med. 2003;139:253-7.

  28. Burgess KR, Lucas SJE, Shepherd K, et al. Worsening of central sleep apnea at high altitude − a role for cerebrovascular function. J Appl Physiol. 2013;114:1021-8.

  29. Villafuerte FC, Cárdenas R, Monge CC. Optimal hemoglobin concentration and high altitude: a theoretical approach for Andean men at rest. J Appl Physiol. 2004;96:1581-8.

  30. Wang X, Callacondo D, Rojas J, et al. Erythrocytosis in chronic mountain sickness (CMS) in Andeans. Blood. 2014;124:4873.

  31. Mejia CR, Quiñones-Laveriano DM, Cruzalegui-Solari CC, Arriola-Quiroz I, Perez-Perez L, Gomero R. Edad como factor de riesgo para desarrollar síndrome metabólico en trabajadores mineros a gran altura. Rev Argent Endocrinol Metab. 2016; 53(1):29-35.




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