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Órgano Oficial de el Colegio Mexicano de Urología

2003, Number 3

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Bol Col Mex Urol 2003; 18 (3)

Infections caused by Chlamydia trachomatis and Mycoplasma sp. Their relationship to male infertility

Gallegos-Ávila G

Language: Spanish
References: 90
Page: 106-112
PDF size: 84.47 Kb.


ABSTRACT

Among the diverse causes of male infertility, genital infections, usually underestimated, have shown up as one of the most important causes of several reproductive disorders during the last years. Chlamydia trachomatis and some Mycoplasma species, specially Ureaplasma, are pathogens which arise from the wet mucous membranes and install themselves in glands and the coating epithelium of the genital ducts. These bacteria directly affect the spermatozoid by adhering to it and penetrating into its cytoplasm; but they also do this in an indirect way through oxygen reactive species, harmful molecules which are released during the inflammatory response. Even though the information keeps on being contradictory, several reports have related the infections caused by Mycoplasma and Chlamydia to seminal quality deterioration, spermatic dysfunction, and connubial infertility.


REFERENCES

  1. Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am 2002; 29: 817-27.

  2. Aitken, RJ, Buchingham DW, Brindle et al. Analysis of sperm movement in relation to the oxidative stress created by leukocytes in washed sperm preparations and seminal plasma. Hum Reprod 1995; 10: 2061-1071.

  3. Aitken RJ. Molecular mechanisms regulation human sperm function. Mol Hum Reprod 1997; 3: 169-173.

  4. Baseviciene I, Labanauskas L, Vysniauskaite N. Early diagnosis of genital Chlamydia trachomatis infection among adolescent girls. Medicina (Kaunas) 2003; 39: 138-43.

  5. Blanchard A, Hentchel J, Duffy L, Baldus K. Detection of Ureaplasma urealyticum by polymerase chain reaction in the urogenital tract of adults, in amniotic fluid, and in the respiratory tract on newborns. Clin Infect Dis 1993; 17 (Suppl. 1): S148-S153.

  6. Bragina EY, Gomberg MA, Dmitriev GA. Electron microscopic evidence of persistent chlamydial infection following treatment. J Eur Acad Dermatol Venereol 2001; 15: 405-9.

  7. Brunham RC, Maclean IW, Binns B, Peeling RW. Chlamydia trachomatis: its role in tubal infertility. J Infect Dis 1985; 152: 1275-82.

  8. Bruner H, Weidner W, Shiefe HG. Quantitative studies on the role of Ureaplasma urealyticum in non-gonococcal urethritis and chronic prostatitis. Yale J Bio Med 1983; 56: 545-550.

  9. Busolo F, Zanchetta R. Mycoplasmic localization patterns on spermatozoa from infertile men. Fertil Steril 1984; 43: 110-114.

  10. Cassel GH, Waites KB, Watson HL, Crouse KT, Harasawa R. Ureaplasma urealyticum intrauterine infection: Role in prematurity and disease in newborns. Clin Microbiol Rev 1993; 6: 69-87.

  11. Centers for Disease Control and Prevention (CDC). Assisted Reproductive Technology Success Rates. Reprod Heal Nat Sum Fertil Clin Rep 2000: 1-12.

  12. Colpi GM, Negri L, Piffaretti-Yannez A, Balerna M. Inflammatory pathology of the genital tract and male infertility. A short review. Acta Eur Fertil 1989; 20: 125-32.

  13. Custo GM, Lauro V, Saitto C, Frongillo RF. Chlamydial infection and male infertility: an epidemiological study. Arch Androl 1989; 23: 243-248.

  14. De Silva, NS, Quinn PA. Localization of endogenous activity of phospholipases A and C in Ureaplasma urealyticum. J Clin Microbiol 1991; 29: 1498-1503.

  15. De Borges RJ, Carvallo I. Ultraestructura de Chlamydia en células descamadas del cuello. IDEA 1987; 25: 257-264.

  16. De Louvois J, Beader M. Frequency of Mycoplasma in fertile and infertile copules. Lancet 1974; 1: 1073

  17. Devonshire P, Hillman R, Capewell S, Clark BJ. Knowledge of Chlamydia trachomatis genital infection and its consequences in people attending a genitourinary medicine clinic. Sex Transm Infect 1999; 75: 409-11.

  18. Díaz-Gutiérrez OG, Gallegos de Lerma MG. Características de estructura fina de Mycoplasma sp. en semen humano. Enfermedades infecciosas microbiología 1996; 5 ISNN 14050994.

  19. Díaz Gutiérrez OG, Gallegos AG. Ureaplasma urealyticum diagnosis by PCR in infertile men and its clinical relevance. J Androl 1999b; 20: 38.

  20. Diquelou JY, Pastorini E, Feneux D, Gicquel JM. The role of Chlamydia trachomatis in producing abnormal movements by spermatozoa. J Gynecol Obstet Biol Reprod (Paris) 1989; 18: 615-25.

  21. Dille BJ, Butzen CC, Birkenmeyer LG. Amplification of Chlamydia trachomatis DNA by ligase chain reaction. J Clin Microbiol 1993; 31: 2350-2352.

  22. Eggert-Kruse W, Rohr G, Probst S, Rusu R, Hund M, Demirakca T, Aufenanger J, Runnebaum B, Petzoldt D. Antisperm antibodies and microorganisms in genital secretions a clinically significant relationship. Andrologia 1998; 30 Suppl1: 61-71.

  23. Erbengi T. Ultrastructural observations on the entry of Chlamydia trachomatis into human spermatozoa. Hum Reprod 1993; 8: 416-21.

  24. Fenton KA. Screening men for Chlamydia trachomatis infection: have we fully explored the possibilities. Commun Dis Public Health 2000; 3: 86-9.

  25. Fowlkes DM, McLeod J. T-mycoplasmas and human infertility: Correlation with infection with alterations in seminal parameters. Fertil Steril 1975; 26: 1212.

  26. Fowlkes DM, Dooher GB, Olearly WM. Evidence by scanning electron microscopy for an association between spermatozoa and T-mycoplasmas in men of infertile marriage. Fertil Steril 1975; 26: 1203-1211.

  27. Gattuccio F, Di Trapani D, Romano C, Turtulici B, Milici M, Pavone C, D’Alia O, Alaimo R, Latteri MA. Urogenital inflammations: aetiology, diagnosis and their correlation with varicocele and male infertility. Acta Eur Fertil 1988; 19: 201-8.

  28. Gaudoin M, Rekha P, Morris A, Lynch J, Acharya U. Bacterial vaginosis and past chlamydial infection are strongly and independently associated with tubal infertility but do not affect in vitro fertilization success rates. Fertil Steril 1999; 72: 730-2.

  29. Gnarpe H, Friberg J. Mycoplasma and human reproductive failure I: The occurrence of different Mycoplasma in couples with reproductive failure. Am J Gineacol Obstet 1972; 114: 727.

  30. Gregoriou O, Botsis D, Papadias K, Kassanos D, Liapis A, Zourlas PA. Culture of seminal fluid in infertile men and relationship to semen evaluation. Int J Gynaecol Obstet 1989; 28: 149-53.

  31. Greendale GA, Haas ST, Holbrook K, Walsh B, Schachter J, Phillips RS. The relationship of Chlamydia trachomatis infection and male infertiliy. Am J Public Health 1993; 83: 996-1001.

  32. Grossgebauer K, Hennig A. Ureaplasma-infected human sperm in infertile men. Arch Androl 1984; 12 Suppl: 35-41.

  33. Gump D, Gibson M, Ashikaga T. Lack of association between genital mycoplasmas and infertility. N Engl J Med 1984; 12: 937-941.

  34. Hellstrom WJG, Neal DE Jr. Diagnosis and therapy of male genital tract infections. Infertility and Reproductive Medicine Clinics of North America 1992; 3: 399-427.

  35. Jong Z, Pontonnier F, Plante P, Perie N, Talazac N, Mansat A, Chabanon G. Comparison of the incidence of Ureaplasma urealyticum in infertile men and in donors of semen. Eur Urol 1990; 18: 127-131.

  36. Kalugdam T, Chan PJ, Seraj IM. Polymerase chain reaction enzyme-linked immunosorbent assay detection of Mycoplasma consensus gene in sperm with low oocyte penetration capacity. Fertil Steril 1996; 66: 703-797.

  37. Keck C, Gerber-Schafer C, Clad A, Wilhelm C, Breckwoldt M. Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 1998; 4: 891-903.

  38. Kinninen A, Molander P, Laurilla A, Rantala I, Morrison R, Lehtinen M, Arttunen R, Tiitinen A, Paavonen J, Surcel MH. Chlamydia trachomatis reactive Tlymphocytes from upper genital tract tissue specimens. Hum Reprod 2000; 15: 1484-1489.

  39. Kjaergaard N, Kristensen B, Hansen ES, Farholt S, Schonheyder HC, Uldbjerg N, Madsen H. Microbiology of semen specimens from males attending a fertility clinic. APMIS 1997; 105: 566-70.

  40. Knight ST, Lee SH, Davis CH, Morman DR, Hodinka RL, Wyrick PB. In vitro activity of monoxy-9 McCoy cells infected with Chlamydia trachomatis. Sex Transmitted Dis 1987; 14: 165-173.

  41. Kohn FM, Erdmann I, Oeda T, el Mulla KF, Schiefer HG, Schill WB. Influence of urogenital infections on sperm functions. Andrologia 1998; 30 Suppl 1: 73-80.

  42. Kundsin RB. Mycoplasmas in genitourinary tract infection and reproductive failure. In: Progress in Gynecology. Sturgis, S. H., Taymor, M. L. (Eds.) New York, Grune&Stratton, 1970; pp 275.

  43. Law H, Itkonnen O, Linwood CA. The sulfogalactolipid binding protein SLIP 1; a concerved function for a concerved protein. J Cell Physiol 1988; 137: 462-468.

  44. Levy R, Layani-Milon MP, Giscard D’Estaing S, Najioullah F, Lornage J, Aymard M, Lina B. Screening for Chlamydia trachomatis and Ureaplasma urealyticum infection in semen from asymptomatic male partners of infertile couples prior to in vitro fertilization. Int J Androl 1999; 22: 113-8.

  45. Licciardi F, Grifo JA, Rosenwaks Z, Witkin SS. Relation between antibodies to Chlamydia trachomatis and spontaneous abortion following in vitro fertilization. J Assist Reprod Genet 1992; 9: 207-10.

  46. Lingwood CA, Queen PA, Wilansky S et al. Common sulfoglycolipid receptor for mycoplasmas involved in animal an human infertility. Biol Reprod 1990; 43: 694-697.

  47. Lu J, Liang Z, Han Z. The relationship between female infertility and genital inflammation of Chlamydia trachomatis. Fertil Steril 1999; 71: 1066-9.

  48. Mardh P, Moller BR, Paavonen J. Chlamydial infection of the female genital tract with emphasis on pelvic inflammatory disease. A review of Scandinavian Studies. Sex Transmitted Dis 1981; 8: 140-155.

  49. Mavrov GI. An electron microscopic study of the interaction of Chlamydia trachomatis with human spermatozoa. Mikrobiol Z 1995; 57: 74-9.

  50. Meier B, Habermelh GG. Effect of superoxide dismutase and catalase in mollicutes and relase of reactive oxygen species. Arch Biochem Biophys 1990; 277: 74-79.

  51. Meseguer MA, Martinez-Ferrer M, De Rafael L. Differenttial counts of Ureaplasma urealyticum in male urological patients. J Infect Dis 1984; 149: 657-659.

  52. Moller BR, Mardh PA. Pathogenic role of Chlamydia in urogenital infections. Nord Med 1980; 95: 128-32.

  53. Moulder JW. Comparative biology of intracellular parasitism. Microbiol Rev 1985; 49: 298-337.

  54. Moulder JW, Hatch TP, Kuo CC, Schachter J, Storz J. Order II Chlamydiales. In Kreig, NR and Holt JG, Eds. Bergeys Manual of systematic Bacteriology. Williams & Wilkins Baltimore MD, 1984: 729-739.

  55. Narcio ML, Arredondo JL, Zaldivar A, Quesnel C, Casanova G, Guerra CF, Sosa IE, Zuniga M, Flores S, Guajardo R. Microbial etiology of mild and moderate pelvic inflammatory disease. Ginecol Obstet Mex 1998; 66: 309-15.

  56. Ness RB, Markovic N, Carlson CL, Coughlin MT. Do men become infertile after having sexually transmited urethritis An epidemiologic examination. Fertil Steril 1997; 68: 205-13.

  57. Núñez-Calonge R, Caballero P, Redondo C, Baquero F, Martinez-Ferrer M, Meseguer MA. Ureaplasma urealyticum reduces motility and induces membrane alterations in human spermatozoa. Hum Reprod 1998; 13: 2756-61.

  58. Nunez-Troconis JT. Mycoplasma hominis and Ureaplasma urealyticum in different gynecologic diseases. Invest Clin 1999; 40: 9-24.

  59. Ochsendorf FR, Ozdemir K, Rabenau H, Fenner T, Oremek R, Milbradt R, Doerr HW. Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. Trachomatis specific and associated with an inflammatory response. J Eur Acad Dermatol Venereol 1999: 12: 143-42.

  60. Ostaszewska I, Zdrodowska-Stefanow B, Badyda J, Pucilo K, Trybula J, Bulhak. Chlamydia trachomatis: probable cause of prostatitis. Int J STD & AIDS 1998; 9: 350-3.

  61. Paavonen J, Eggert-Kruse W. Chlamydia trachomatis: impact on human reproduction. Hum Reprod Update 1999; 5: 433-47.

  62. Paavonen J, Wolner-Hanssen P. Chlamydia trachomatis: a major treat to reproduction. Hum Reprod 1989; 111-124.

  63. Potts JM, Sharma R, Pasqualotto F, Nelson D, Hall G, Agarwal A. Association of ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol 2000; 163: 1775-8.

  64. Rezacova J, Masata J, Pribylova M, Drazd’akova M. Chlamydia trachomatis in men with impaired fertility. Ceska Gynekol 1999; 64: 371-5.

  65. Rodriguez R, Hernandez R, Fuster F, Torres A, Prieto P, Alberto J. Genital infection and infertility. Enferm Infecc Microbiol Clin 2001; 19: 261-6.

  66. Rosas AJ, Toca PL, Diaz EC, Nava FJ. Chlamydia trachomatis infection in the cervix uterine. Ginecol Obstet Mex 1993; 61: 326-8.

  67. Shachter J. Chlamydial infections (first of three parts). N Engl J Med 1978; 298: 428-435.

  68. Shachter J. The intracellular life of Chlamydia. Curr Top Microbiol Immunol 1988; 138: 109-139.

  69. Schachter J. Biology of Chlamydia trachomatis, In: Holmes KK, Mardh P.A., Sparling P.F., Wiesner P.J., Sexually transmitted Diseases 2nd edn. Mac Graw-Hill. N. Y. 1990: 167-180.

  70. Sharara FI, Queenan JT Jr. Elevated serum Chlamydia trachomatis IgG antibodies. Association with decreased implantation rates in GIFT. J Reprod Med 1999; 44: 581-6.

  71. Shepard MC. Quantitative relationship of Ureaplasma urealyticum to the clinical course of non gonococcal urethritis in the human male. INSERM 1974; 33: 375-379.

  72. Solis EA, Gatti VN, Bouvet BR, Brufman AS, Catalina Provenzal O, Feldman R. Round cells in semen and genital infections. Arch Esp Urol 2000; 53: 101-5.

  73. Stanislavov R. Leukocytes in human seminal fluid. Akush Ginekol (Sofiia) 1999; 3: 20-1.

  74. Soffer Y, Ron-El R, Golan A. Male genital mycoplasmas and Chlamydia trachomatis culture: its relationship with accessory gland function, sperm quality and autoimmunity. Fertil Steril 1990; 53: 331-336.

  75. Stalheim OHV, Porctor SJ, Gallager SG. Growth with effects of Ureaplasmas (T mycoplasmas) in bovine oviductal organ cultures. Infect Immune 1976; 13; 915-925.

  76. Swanson J, Sschenbach DA, Rusell AE, Holmes KK. Light an electron microscopic study of Chlamydia trachomatis infection of the uterine cervix. J Infection Diseases 1975; 131: 678-683.

  77. Swenson ChE, Toth CL, Wolfgruber L, Olearly M. Asymptomatic bacteriospermia in infertile men . Andrologia 1980; 12: 7-11.

  78. Szöke L, Török E, Dósa E, Nagy and S. Scultéty. The possible role of anaerobic bacteria in chronic prostatitis. Int J Andrology 1998; 21: 163-168.

  79. Talkington DF, Davis JK, Canupp KC, Garret BK, Waites KB, Huster GA, Cassel GH. The effects of three serotypes of Ureaplasma urealyticum on spermatozoa motility and penetration in vitro. Fertil Steril 1991; 55: 170-176.

  80. Taylor-Robinson D. Mycoplasma genitalum-an update-. Int J STD & AIDS 2002; 13: 145-151.

  81. Taylor-Robinson DT. Mycoplasmas and infertiliy. Nature 1974; 248-267.

  82. Tood WJ, Cadwell HD. The interaction of Chlamydia trachomatis with hosts cells: Ultrastructural studies of the mechanism of release of a Biovar II strain from He-La 229 Cells. J Infect Dis 1985; 151: 1037-1044.

  83. Trum JW, Pannekoek Y, Spanjaard L, Bleker OP, Van Der Veen F. Accurate detection of male subclinical genital tract infection via cervical culture and DNA hybridization assay of the female partner. Int J Androl 2000; 23: 43-5.

  84. Villegas H, Pinon M, Shor V, Karchmer S. Electron microscopy of Chlamydia trachomatis infection of the male genital tract. Arch Androl 1991; 27: 117-26.

  85. Weidner W, Shiefer HG, Garbe CH. Acute nongonococcal epididimytis etiological and therapeutic aspects. Drugs 1987; 34: 111-117.

  86. Westrom LV. Chlamydia trachomatis-clinical significance and strategies of intervention. Semin Dermatol 1990; 9: 117-25.

  87. Wolff H. Methods for the detection of male genital tract inflammation. Andrologia 1998; 30 Suppl 1: 35-9.

  88. 88 Wolner-Hanssen P, Mardh PA. In vitro tests of the adherence of Chlamydia trachomatis to human spermatozoa. Fertil Steril 1984; 42: 102-107.

  89. Xu C, Sun GF, Zhu YF, Wang YF. The correlation of Ureaplasma urealyticum infection with infertility. Andrologia 1997; 29: 219-226.

  90. Zalata, AA, Christophe AB, Depuydt CE, Schoonjans F. White blood cells cause oxidative damage to the fatty acid composition of phospholipids of human spermatozoa. Int J Androl 1998; 21: 154-162.




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