2017, Number 2
Therapeutic response in patients with polycistic ovary syndrome
Language: Spanish
References: 30
Page: 191-201
PDF size: 933.77 Kb.
ABSTRACT
Background: polycystic ovary syndrome is an heterogeneous disorder; it has been recognized as the main cause of infertility on women during reproductive ages.Objective: to determine the therapeutic response in patients suffering from polycystic ovary syndrome in Camaguey hospital "Manuel Ascunce Domenech" at endocrinology consultation from January 2013 to January 2015. Methods: an observational descriptive and longitudinal study was carried out. The universe was sample by all patients who were diagnosed with polycystic ovary syndrome. The data were processed by descriptive statistics.
Results: 66, 97 % of patients answered to the treatment and 70, 00 % of patients who had normoandrogenic type answered correctly too. After the treatment 55, 50 % of patients continuous with ovary volume higher than 13 mL.
Conclusions: the most important variation were to reduce blood levels of testosterone and to increase blood levels of progesterone. The therapeutic combination more used was hygienic-dietetic changes plus metformina.
REFERENCES
Florez JC. Genetic Susceptibility for Polycystic Ovary Syndrome on Chromosome 19: advances in the genetic dissection of complex reproductive traits. J Clin Endocrinol Metab [Internet] 2005 Dec [citado 2013 May 5];90(12):[about 12 p.]. Available from: http://press.endocrine.org/doi/10.1210/jc.2005-2204?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Acosta Cedeño A, Monteagudo Peña G, Menocal Alayón A. Patrón hormonal de mujeres con diagnóstico clínico y ecográfico del síndrome de ovarios poliquísticos. Rev Cubana Endocrinol [Internet]. Ago 2004 [citado 2 Feb 2015];5(2):[aprox. 6 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532004000200003&lng=es.
Guo M, Chen ZJ, Eijkemans MJ, Goverde AJ, Fauser BC, Macklon NS.Comparison of the phe-notype of Chinese versus Dutch Caucasian wom-en presenting with polycystic ovary syndrome and oligo/amenorrhea. Hum Reprod [Internet]. 2012 May [citado 2015 Feb 2];27(5):[about 10 p.]. Available from: http://humrep.oxfordjournals.org/content/27/5/1481.long
Bungum L, Franssohn F, Bungum M, Humai-dan P, Giwercman A. The circadian variation in Anti-Mullerian hormone in patients with polycys-tic ovary syndrome differssignificantly from nor-mally ovulating women. PLoS One [Internet]. 2013 Sep 4 [citado 2015 Feb 2];8(9):[about 5 p.]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762839/.
Witherby S, Johnson J, Demers L, Mount S, Littenberg B, Maclean CD, et al. Topical testos-terone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study. Oncologist [Internet]. 2011 [citado 2015 Feb 2];16(4):[about 12 p.]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228118/.
Elraiyah T, Sonbol MB, Wang Z, Khairalseed T, Asi N, Undavalli C, et al. Clinical review: The benefits and harms of systemic testosterone the-rapy in postmenopausal women with normal adrenal function: a systematic review and meta-analysis. J Clin Endocrinol Metab [Internet]. 2014 [citado 2015 Feb 2];99(10):[about 8 p.]. Available from: http://press.endocrine.org/doi/10.1210/jc.2014-2262?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Fernandes T, Costa Paiva LH, Pinto Neto AM. Efficacy of vaginally applied estrogen, testostero-ne, or polyacrylic acid on sexual function in post-menopausal women: a randomized controlled trial. J Sex Med [Internet]. 2014 May [citado 2015 Feb 2];11(5):[about 7 p.]. Available from: http://www.pubfacts.com/detail/24612478/Efficacy-of-vaginally-applied-estrogen-testosterone-or-polyacrylic-acid-on-sexual-function-in-postme
Haring R, Hannemann A, John U, Radke D, Nauck M, Wallaschofski H, et al. Age-specific ref-erence ranges for serum testosterone and an-drostenedione concentrations in women meas-ured by liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab [Internet]. 2012 Feb [citado 2015 Feb 2];97(2):[about 12 p.]. Available from: http://press.endocrine.org/doi/10.1210/jc.2011-2134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed