Basurto-Alcántara FJ, Mondragón VRL, Atilano-López D, Montaraz CJA, Marques SMJ, Rosas SP, Marroquín-Segura R

Language: English/Spanish
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Page: 209-216
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ABSTRACT

In this paper the normal blood values of a new naked mice mutant known as et/et were compared vs CD1 and heterocigotic et/+. Leukocyte and differential counts showed that total leukocytes, lymphocytes, monocytes and eosinophils were significantly higher (P ‹ 0.05) in the et/et mice than in the CD1, and that there was no difference with the et/+ ones. In 89% of the naked mice, neutrophil hypersegmentation was observed, while only a 10% of the heterocygotes presented it, and it was not observed in CD1 mice. Total lymphocytes CD3+ and CD8+ populations, was higher in et/et (P ‹ 0.05) than in CD1 mice, and without difference in et/+ mice. Hematocrite values were higher (P ‹ 0.05) in the et/et mice than in CD1 ones. In the plasma protein count, the et/et mice had less density as compared to the CD1 ones. The et/et males presented a significantly higher (P ‹ 0.05) concentration in the alphaglobulin fraction than in the et/et females (8.94% ± 1.81 vs 3.49% ± 0.69). There were significant differences in the spleen lymphoid cell count between the et/et mice which had 43 cells/50 µl compared to 97.5 in the CD1 mice. Meanwhile et/+ mice had an intermediate value that lacked statistical significance. With the results in the analyses it is concluded that: the et/et mice have within their genetic characteristics a leukocytosis with lymphocytosis monocytosis and circulating eosinophilia, and lymphopenia in the spleen, as well as a neutrophil hypersegmentation. This finding is considered as an associated possibility to adrenal hypertrophy reported by others authors.