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ISSN 0028-3851 (Print)

2002, Number 3

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Rev Neurol Neurocir Psiquiat 2002; 35 (3)

Apolipoprotein E genotyping in Mexican people subjects with Alzheimer disease

Silva EJG, Berumen CJ, Valdés ERA, Franco LMO, Siller LJJ, Moguel MJ

Language: Spanish
References: 15
Page: 119-124
PDF size: 567.93 Kb.


ABSTRACT

Background. Diverse genetic factors of susceptibility to the Alzheimer Disease (AD) has been proposed. The more studied has been the polymorphism of Apolipoprotein E gene (ApoE).
Objective. To evaluate the alleles frequency of ApoE, in a Mexican population. We settled down if the genotyping of ApoE is a diagnosis element associated with the oxidative stress and AD.
Method. We were carried out the genotyping of ApoE in 72 individuals (36 of the control group and 36 with AD). Patients were recruited from the Geriatric and Neurologic services at the Military Central Hospital and the Specialty Medical Unit.
Results. The more common allele in the total population was E3 with a 98% in their homocygote and heterocygote forms, E4 with a 23.6 and E2 with a 4.1% frequency. In the control group the predominant genotype was E3E3 (80%), followed by E3E4 (16.6%) and just one person had the high risk genotype E4E4 (2.7%). In the AD group the predominant genotype was E3E3 representing 63.8%, followed by E3E4 (27.7%) and E2E3 (8.3%).
Conclusions. It was meaningful statistic differences (p › 0.001) for age and sex between the control group and the group with AD. For alleles and genotypes frequency in both groups they were not significant statistic differences. These findings suggest that another different factors besides the genotype, are able to influence AD presentation, and such factors could cause differences in the oxidative level of stress in AD patients as well as individuals with a successfull ageing.


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