Rodríguez MJR, García RM

Language: Spanish
References: 10
Page: 161-164
PDF size: 266.36 Kb.

ABSTRACT

Merkel cell carcinoma is an infrequent tumor which has a very aggressive evolution and a high propensity for locoregional recurrences and metastases. Sun-exposed areas are mainly affected, especially in elderly people. Its incidence has quadrupled in the last decades due to population ageing and thanks to immunohistochemistry techniques that have allowed a higher number of people diagnosed. Pathogenesis of Merkel cell carcinoma is not precise, but ultraviolet radiation, immunosupression and presence of polyomavirus in the tumor genome seem to play an important role in the development of this neoplasm. The aim of this article is to report a clinical case of the natural history of this rare skin tumor, as well as, to explain in detail some histologic and immunohistochemical features necessary for its diagnosis and staging, given its great importance in establishing a prognosis for these patients.

REFERENCES

1. Quijano Moreno SL. Carcinoma de células de Merkel. Actualización. Rev Esp Patol. 2016;49(3):158-68.

2. Llombart B, Requena C, Cruz J. Actualización en el carcinoma de células de Merkel: Epidemiología, etiopatogenia, clínica, diagnóstico y estadificación. Actas Dermo-Sifiliográficas. 2017 Mar.;108(2):108-19.

3. Vila Blanco JM, Nabhan S. Carcinoma de células de Merkel. Estudio de 3 casos. Rev Chilena Cir. 2016;68(6):456-61.

4. Méndez Matthey V, Torres Grabiel L. Carcinoma cutáneo de células de Merkel de presentación acral. Rev Finlay. 2016;6(2):156-66.

5. Fields RC, Busam KJ, Chou JF, Recurrence and survival in patients undergoing sentinel lymph node biopsy for Merkel cell carcinoma: analysis of 153 patients from a single institution. Ann Surg Oncol. 2011;18(9):2529-37.

6. Chang P, Machuca L. Mucocutaneous malignancies in patients with AIDS Report of 32 cases. Our Dermatol (Online)/Nasza Dermatol (Online). 2016;7(3).

7. Freitas De Brito F. Carcinoma de células de Merkel: apresentação clínica, dermatoscópica e imuno-histoquímica de um tumor raro. Surg & Cosmet Dermatol. 2016;8(3):266-70.

8. Radonich JE. Carcinoma de células de Merkel asociado a linfoma B folicular. Arch Argent Dermatol. 2016;66(2):45-8.

9. Bravo Puccio F. Virus como inductores de neoplasias cutáneas. Rev Peruana Med Exp Salud Púb. 2016;30(1).

10. Roesch-Dietlen F.