2017, Number 2
<< Back Next >>
Medicentro 2017; 21 (2)
Histopathological changes in the liver of Wistar rats with experimental diabetes mellitus
Muro MI, Batista HNE, Béquer ML, Gómez HT
Language: Spanish
References: 10
Page: 154-156
PDF size: 301.53 Kb.
ABSTRACT
An experimental study aimed at identifying the histopathological changes in liver as a consequence of diabetes was conducted in the Biomedical Research Unit at the University of Medical Sciences, in Villa Clara. Newborn female Wistar rats were studied and divided into two experimental groups: a non-diabetic control and another one, to which moderate diabetes was induced by subcutaneous injection of 100 mg/kg body weight of streptozotocin. Despite no statistical differences were found among the evaluated variables in both study groups, the frequency of occurrence liver damage was higher in the group inoculated with streptozotocin.
REFERENCES
American Diabetes Association (ADA). Standards of medical care in diabetes. Diabetes Care. 2014;37(Suppl. 1):S14-S80.
Ministerio de Salud Pública. Anuario Estadístico de Salud 2015. [internet]. La Habana: Dirección Nacional de Registros Médicos y Estadísticas de Salud; 2016 [citado 14 nov. 2016]. Disponible en: http://files.sld.cu/dne/files/2016/04/Anuario_2015_electronico-1.pdf
Guías ALAD sobre el diagnóstico, control y tratamiento de la diabetes mellitus Tipo 2 con Medicina Basada en Evidencia. Edición 2013. Rev ALAD. 2013:1-142.
Bequer Mendoza L, Gómez Hernández T, Molina JL, Artiles D, Bermúdez R, Clapés S. Acción diabetogénica de la estreptozotocina en un modelo experimental de inducción neonatal. Biomédica. 2016;26(2).
Gómez T, Bequer L, Sánchez C, de la Barca M, Muro I, Reyes MA, et al. Inducción neonatal de hiperglucemias moderadas: indicadores metabólicos y de estrés oxidativo en ratas adultas. Rev ALAD. 2014;4(4):148-57.
Bequer L, Gómez T, Molina JL, López F, Gómez CL, Clapés S. Inducción de hiperglicemias moderadas en ratas wistar por inoculación neonatal de estreptozotocina. ¿Inyección subcutánea o intraperitoneal? Rev Argent Endocrinol Metab. 2014;51(4):178-84.
Goyal S, Reddy N, Patil K, Nakhate K, Ojha S, Patil C, et al. Challenges and issues with streptozotocin-induced diabetes-A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics. Chem Biol Interact. 2016;244:49-63.
Szkudelski T. Streptozotocin–nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med. 2012:1-10.
Sinzato YK, Lima PH, de Campos KE, Kiss AC, Rudge MV, Damasceno DC. Neonatally-induced diabetes: lipid profile outcomes and oxidative stress status in adult rats. Rev Assoc Med Bras. 2009;55(4):384-8.
Damasceno DC, Netto AO, Iessi IL, Gallego FQ, Corvino SB, Dallaqua B, et al. Streptozotocin-induced diabetes models: Pathophysiological mechanisms and fetal outcomes. BioMed Res Int [internet]. 2014 [citado 6 dic. 2015];2014:[aprox. 11 p.]. Disponible en: https://www.hindawi.com/journals/bmri/2014/819065/