Herrera MM, Fernández CD, Estrada LK, Yera VM, Chaviano MS, Pérez RLM, González-Herrera I

Language: Spanish
References: 20
Page: 127138
PDF size: 407.66 Kb.

ABSTRACT

Introduction: human longevity is a complex phenotype with multiple determinants where incomprehensible genetic and environmental factors are involved.
Objective: to determine heritability of longevity in a group of families with exceptionally long life.
Methods: a genealogical tree of 340 people belonging to families from Villa Clara with exceptionally long life was made for studying genetic epidemiology of longevity; concordance of phenotype in siblings and spouses was analyzed, as well as, the correlation of phenotype in 2 125 couples of siblings evaluated according to gender and in 302 couples of long-lived probands and spouses was analyzed by means of Pearson correlation coefficient. Heritability in the narrow sense was determined according to the intraclass correlation coefficient between siblings and according to the correlation between spouses.
Results: phenotype had a high concordance between siblings of the proband, being higher than the one found between spouses; heritability estimate was 0.35 in a design that consider couples including the proband. In the design, where all independent couples of siblings were used, but the proband was excluded, heritability was 0.39 for families with a male proband and 0.58 for families with female probands.
Conclusions: moderate heritability shows an increase of years lived as a continuous phenotype. High concordance for longevity between spouses without any parenthood between them demonstrates that environmental factor of the phenotype is not insignificant.

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