Gómez-Alarcón A, Gómez-García MT, García-de la-Torre JP, Del Valle-Morón M, Arones-Collantes MA, González-de Merlo G

Language: Spanish
References: 20
Page: 172-179
PDF size: 371.84 Kb.

ABSTRACT

Background: The vulvar cancer is the fourth more frequent neoplasia after the endometrial, cervix and ovarian cancer. Normally, it has been related to old women of ages from 70 to 80 years old. Rarely, it has been detected cases in adult or young women. However, its incidence has been increased in the last years and in more early years.
It is for this change in the incidence and its appearance in early years why a possible etiology has been looked for, opening different hypothesis that go from that related to the HPV to those that study an inflammatory chronic process as the basis for the carcinogenesis.
Clinic case: In this article, it has been presented the case of a woman who is 34 years old with negative VPH that made her debut with epidermoid carcinoma of the vulva moderately different and on purpose of the case, we do a revision of the literature existent.
Conclusions: Vulvar cancer diagnosed in young women as in older, but with different trends, risk factors and natural history. The case reported here escapes the theories studied so far so needed new lines of inquiry to investigate this form of presentation young woman, without HPV infection.

REFERENCES

1. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol 2006;107:1018-22.

2. American Cancer Society. Cancer referent information. Available at: http://www.cancer. org. Accessed Sept. 1, 2008.

3. Messing MJ, Gallup DG. Carcinoma of the vulva in young woman. Obstet Gynecol 1995; 86: 51-4.

4. Al-Ghamdi A, Freedman D, Miller D, Poh C, Rosin M, Zhang L, Gilks CB. Vulvar Squamous Cell Carcinoma in Young Wo men: A Clinicopathologic Study of 21 Cases. Gynecologic Oncology 2002;84: 94-101.

5. Jones RW, Baranyai J, Stables S. Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. Obstet Gynecol 1997;90:448-52.

6. Jones IS, Crandon A, Sanday K. Squamous Cell Carcinoma of the Vulva: A Comparison Between Women 35 Years or Younger and 90 Years or Older. Journal of Lower Genital Tract Disease 2013;17: 262-272.

7. Toki T, Kurman RJ, Park JS, Kessis T, Daniel RW, Shak KV. Probable nonpapillomavirus etiology of squamous cell carcinoma of the vulva in older women: a clinicopathologic study using in situ hybridization and polymerase chain reaction. Int J Gynecol Pathol 1991;10:107-125.

8. Hording U, Daugaard S, Junge J, Lundvall F. Human papilloma viruses and multifocal genital neoplasia. Int J Gynecol Pathol 1996;15:230-4.

9. Togo-Peraza JM, Togo-Osuna LR, Montoya-Romero JJ. Carcinoma vulvar in situ en mujer de 19 años, reporte de un caso y revisión de la bibliografía. Ginecol Obstet Mex 2014;82:558-562.

10. Lanneau GS, Argenta PA, Lanneau MS, et al. Vulvar cancer in young women: demographic features and outcome evaluation. Am J Obstet Gynecol 2009;200:645.e1-645.e5.

11. Chase DM1, Lin CC, Craig CD, Fedewa SA, Virgo KS, Farley JH, Halpern M, Monk BJ. Disparities in Vulvar Cancer Reported by the National Cancer Database: Influence of Sociodemographic Factors. Obstet Gynecol. 2015;126:792-802.

12. Echevarri C, Stoler MH, Valente PT. Vulvar Keratinizing Squamous Cell Carcinoma in a 26-year-old woman. Arch Pathol Lab Med 2001; 125: 267-70.

13. van Hoeven KH, Kovatich AJ. Immunohistochemical staining for proliferating cell nuclear antigen, Bcl-2, and Ki-67 in vulvar tissues. Int J Gynecol Pathol 1996;15:10-6.

14. Joura EA, Leodolter S, Hernandez-Avila M, Wheeler CM, Perez G, Koutsky LA, et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007;369:1693-702.

15. Carter J, Carlson J, Fowler J, Hartenbach E, Adcock L, Carson L, Twiggs LB. Invasive vulvar tumors in young women— a disease of the immunosuppressed? Gynecol Oncol 1993;51:307-10.

16. van den Einden LC, Massuger LF, Jonkman JK, Bult P, de Hullu JA, Bulten J. An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis. Mod Pathol. 2015;28(2):295-302.

17. Hopkins MP, Reid GC, Johnston CM, Morley GW. A comparison of staging systems for squamous cell carcinoma of the vulva. Gynecol Oncol 1992;47:34-7.

18. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009;105:103-4.

19. Hacker NF. Revised FIGO staging for carcinoma of the vulva. Int J Gynaecol Obstet 2009;105:105-6.

20. Tabbaa ZM, Gonzalez J, Sznurkowski JJ, Weaver AL, Mariani A, Cliby WA. Impact of the new FIGO 2009 staging classification for vulvar cancer on prognosis and stage distribution. Gynecol Oncol 2012;127:147-52.