Álvaro-Vásquez J, Bernabé-Del Río C, Maya-Aranda SE, Espinosa-Tavitas M

Language: Spanish
References: 15
Page: 216-220
PDF size: 337.70 Kb.

ABSTRACT

Acute generalized exanthematous pustulosis is a rare entity related to drugs, mostly antibiotics. It is characterized by self-limited, sterile pustules of less than five millimeters on an erythematous base, of benign course, that give in upon removal of the offending drug. The diagnosis is based on the clinical presentation and histopathology. We report the case of a 52-year-old man with acute generalized exanthematous pustulosis associated with ceftriaxone who was diagnosed based on his skin lesions.

REFERENCES

1. Gordon J. Acute generalized exanthematous pustulosis: an uncommon cause of fever and rash. Am J Emerg Med. 2016; 34 (3): 681.e1-2.

2. Sidoroff A, Dunant A, Viboud C, Halevy S, Bavinck JN, Naldi L et al. Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case–control study (EuroSCAR). Br J Dermatol. 2007; 157 (5): 989-996.

3. Abbas M, Holfeld K, Desjardins D, Zimmer J. Pustular psoriasis complicated with acute generalized exanthematous pustulosis. J Dermatol Case Rep. 2014; 8 (2): 42-45.

4. Szatkowski J, Schwartz RA. Acute generalized exanthematous pustulosis (AGEP): a review and update. J Am Acad Dermatol. 2015; 73 (5): 843-848.

5. Nacaroglu HT, Celegen M, Ozek G, Umac O, Karkıner CS, Yıldırım HT et al. Acute generalized exanthematous pustulosis induced by ceftriaxone use. Postepy Dermatol Alergol. 2014; 31 (4): 269-271.

6. Calistru AM, Lisboa C, Cunha AP, Bettencourt H, Azevedo F. Acute generalized exanthematous pustulosis to amoxicillin associated with parvovirus B19 reactivation. Cutan Ocul Toxicol. 2012; 31 (3): 258-261.

7. Mawri S, Jain T, Shah J, Hurst G, Swiderek J. Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease. J Intensive Care. 2015; 3: 47.

8. Miteva L, Kadurina M, Schwartz RA. Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. Acta Dermatovenerol Croat. 2010; 18 (4): 267-270.

9. Kostopoulos TC, Krishna SM, Brinster NK, Ortega-Loayza AG. Acute generalized exanthematous pustulosis: atypical presentations and outcomes. J Eur Acad Dermatol Venereol. 2015; 29 (2): 209-214.

10. Zhang Z, Liu X. Images in clinical medicine. Acute generalized exanthematous pustulosis. N Engl J Med. 2015; 372 (2): 161.

11. Bahuguna A. Acute generalized exanthematous pustulosis: a rare side effect of a common over-the-counter drug, acetylsalicylic acid. Indian Dermatol Online J. 2013; 4 (3): 231-233.

12. Haro-Gabaldon V, Sánchez-Sánchez-Vizcaíno J, Ruiz-Ávila P, Gutiérrez-Fernández J, Linares J, Naranjo-Sintes R. Acute generalized exanthematous pustulosis with cytomegalovirus infection. Int J Dermatol. 1996; 35 (10): 735-737.

13. Manzano S, Guggisberg D, Hammann C, Laubscher B. Acute generalized exanthematous pustulosis: first case associated with a Chlamydia pneumoniae infection. Arch Pediatr. 2006; 13 (9): 1230-1232.

14. Roujeau JC, Allanore L, Liss Y, Mockenhaupt M. Severe cutaneous adverse reactions to drugs (SCAR): definitions, diagnostic criteria, genetic predisposition. Dermatol Sinica. 2009; 27 (2): 203-209.

15. Mohyuddin GR, Al Asad M, Scratchko L, Khaleeq G. Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. Am J Crit Care. 2013; 22 (3): 270-273.