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2016, Number S3

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Rev Med Inst Mex Seguro Soc 2016; 54 (S3)

Association of ovarian tumors with CA-125

Martínez-Acosta JE, Olguín-Cruces VA

Language: Spanish
References: 24
Page: 230-237
PDF size: 287.32 Kb.


ABSTRACT

Background: The tumor marker CA-125 is the most widely used serum marker for ovarian cancer screening. The aim of this paper was to establish the association between histopathologic result of ovarian tumors with serologic CA-125 and utility for the diagnosis of ovarian tumors at a Ginecoobstetric hospital.
Methods: An observational, retrospective, descriptive and longitudinal study, from September 1st 2010 to February 28 2013. All patients with histopathologic report ovarian tumor and CA-125 was selected to analyze the association of ovarian tumors with their histological type, biological behavior, range positivity of CA-125 and its relationship to the pre and postmenopausal state.
Results: Of 1213 patients, 334 were included. Utility of CA-125 in postmenopausal reported positive predictive value of 67.5%, with sensitivity (72%), specificity (82.6%) and negative predictive value (86.1%), both with p = 0.001, mainly in the epithelial origin. In premenopausal a low positive predictive value was reported.
Conclusions: The CA-125 is useful for screening for ovarian cancer in postmenopausal women, mainly for epithelial origin.


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