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2017, Number 1

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Rev Mex Anest 2017; 40 (1)

Changes in hemodynamics and anesthetic depth with fast bolus versus slow bolus of propofol in anaesthetic induction

Páez-Amaya WG, Carrillo-Torres O

Language: Spanish
References: 17
Page: 14-20
PDF size: 235.54 Kb.


ABSTRACT

Background: Propofol is the most common inductor used in general anesthesia because it show the best pharmacokinetic profile, it is a rapid inductor with ideal conditions for tracheal intubation in short time, the main undesirable effect of this is the hypotension. Objective: To compare hemodynamic changes with two different speeds of propofol administration. Material and methods: Clinical trial (prospective, longitudinal, randomized, comparative study). This included 66 patients, with ASA 1-2 clasification of The American Society of Anesthesiologists programed for general anesthesia were included, between 18-49 years old. The group A received propofol 2mg/kilogram of real weight in 10 seconds. The group B received the same dose of this drug in 2 minutes. Results: We find less hemodynamic repercussion in group B than A. SBP (p ‹ 0.00), DBP (p ‹ 0.01) and PAM (p ‹ 0.00) were highly significant, Group A required more administration of ephedrine (56.6% versus 21.2%). It also use more doses of this. In 11.7% of patients who used ephedrine in this group needed norepinephrine. Group A was a faster diminution in BIS values into two initial minutes, but after this we don’t find significative differences. Conclusions: The speed in administration of propofol is directly proportional to hemodynamic changes, with fast bolus is more often needed vasopressor and it needed higher doses, the anesthetic depth after two minutes has no significant difference.


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