Reyes-Pérez RA, Juárez-Pichardo JS, De los Ríos-Soriano G

Language: Spanish
References: 15
Page: 8-13
PDF size: 251.25 Kb.

ABSTRACT

Perioperative pregabalin administration reduces early postoperative pain at rest. Gabapentin and pregabalin have antiallodynic antihyperanalgesic and useful properties for the treatment of neuropathic pain and acute postoperative pain. Objective: To evaluate the effectiveness of premedication with pregabalin and gabapentin in the perioperative laparoscopic cholecystectomy. Material and methods: A double-blind, randomized, prospective and comparative controlled trial was performed in 35 patients under general anesthesia, randomly distributed into 2 groups group I: oral pregabalin 150 mg, group II: oral gabapentin 300 mg preoperatively and postoperative. cardiovascular hemodynamic parameters, spontaneous pain and hyperalgesia, side effects and treatment satisfaction was evaluated. Results: During awakening time, pregabalin group has an average time of 1.89 minutes (p ‹ 0.002) and a heart rate of 61.39 beats per minute (p ‹ 0.05) compared with group II, both groups had lower scores to 5 on the visual analog scale for their hospital stay. Conclusions: Perioperative administration of pregabalin and gabapentin in laparoscopic cholecystectomy is safe and effective in the parameters evaluated.

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