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2016, Number S2

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Rev Med Inst Mex Seguro Soc 2016; 54 (S2)

Association of inflammatory cytokines with bone turnover markers in type 1 diabetes

Molina-Ayala M, Cruz-Soto RC, Vargas-Ortega G, González-Virla B, Ferreira-Hermosillo A, Gregor-Gooch JM, Mendoza-Zubieta V

Language: Spanish
References: 15
Page: 191-195
PDF size: 284.60 Kb.


ABSTRACT

Background: Diabetes mellitus (DM) adversely affects the skeleton and the physiological mechanisms implicated have not been explained sufficiently. Thus, the objective was to identify inflammatory cytokines (IL-1, IL-6 and TNF-alpha) in patients with T1DM and their association with markers of bone formation (sPINP) and markers of bone resorption (sCTX).
Methods: We studied 62 patients of 18 years of age or more with T1DM. We determined the values of HbA1c, vitamin D, inflammatory cytokines, as well as those of markers of bone formation and of markers of bone resorption.
Results: 49 patients were female with a mean age of 33.5 years. We found values of HbA1c › 7.5 in 83 %, vitamin D of 16 ng/mL. In patients with HbA1c ›7.5 we found a positive correlation between TNF-alpha and sCTX (r = 0.43, p = 0.05), IL-6 and sCTX (r = 0.48, p = 0.037). With a model of simple linear regression between IL-6 and sCTX, it was found a beta coefficient of 23.8 with a p = 0.030 (95 % CI = 2-45.6), ie.: for every unit increase in IL-6 there is a sCTX increase of 23.8 pg/mL.
Conclusions: We found a positive association between TNFalpha and IL-6 with the marker of bone resorption (sCTX) in the group of patients with HbA1c › 7.5. The loss of metabolic control was associated with TNF-alpha and IL-6.


REFERENCES

  1. Wherrett DK, Daneman D. Prevention of Type 1 Diabetes. Endocrinol Metab Clin North Am. 2009 Dec; 38(4): 777-90. doi: 10.1016/j.ecl.2009.08.006

  2. Gillespie KM. Type 1 diabetes: pathogenesis and prevention. CMAJ. 2006 Jul 18;175(2):165-70.

  3. Gómez-Díaz RA, Pérez-Pérez G, Hernández-Cuesta IT, Rodríguez-García J del C, Guerrero-López R, Aguilar- Salinas CA, et al. Incidence of type 1 diabetes in Mexico: data from an institutional register 2000- 2010. Diabetes Care. 2012;35(11): e77.

  4. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 4;383(9911):69-82. doi: 10.1016/S0140-6736(13)60591-7.

  5. Miller RG, Secrest AM, Sharma RK, Songer TJ, Orchard TJ. Improvements in the life expectancy of type 1 diabetes. The Pittsburgh Epidemiology of Diabetes Complications study cohort. Diabetes. 2012 Nov;61(11):2987-92. doi: 10.2337/db11-1625.

  6. Bipradas R. Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures. World J Diabetes. 2013 Aug 15;4(4):101-13.

  7. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes: A meta-analysis. Osteoporos Int. 2007 Apr;18(4):427-44.

  8. Dhaon P, Shah VN. Type 1 diabetes and osteoporosis: A review of literature. Indian J Endocrinol Metab. 2014 Mar-Apr; 18(2):159-65.

  9. Khan TS , Frasser LA. Type 1 Diabetes and Osteoporosis: From Molecular Pathways to Bone Phenotype. J Osteoporos. 2015;2015:1-8. doi: 10.1155/2015/174186

  10. Vasikaran S, Cooper C, Eastell R, Griesmacher A, Morris HA, Trenti T, et al. International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis. Clin Chem Lab Med. 2011 Aug;49(8):1271-4. doi: 10.1515/ CCLM.2011.602.

  11. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499-502.

  12. Holick MF, Ninkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

  13. Janghorbani M, Feskanich D, Willett WC, Hu F. Prospective study of diabetes and risk of hip fracture: the nurses’ health study. Diabetes Care. 2006 Jul;29(7):1573-8.

  14. Livingstone S; Scottish Diabetes Research Network Epidemiology Group. Life Expectancy in Type 1 Diabetes: A Scottich Registry Linkage Study. University of Dundee, UK: Scottish Diabetes Research Network Epidemiology Group; 2013. Disponible en http://www.easdvirtualmeeting.org/ resources/3906

  15. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006 Aug 8;114(6):597-605.




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