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2017, Number 1

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Ann Hepatol 2017; 16 (1)

Ongoing Alcohol Consumptions Counteracts the Benefits of Sustained Virological Response in Patients with Well Compensated Hepatitis C Cirrhosis: an Observational Study

Hernaez R, El-Serag H

Language: English
References: 13
Page: 16-20
PDF size: 142.94 Kb.


Text Extraction

A summary of the study in the Journal of Hepatology

Liver fibrosis is an established risk factor for the development of hepatocellular carcinoma (HCC). It is also proven that alcohol is also associated with the development and progression of liver fibrosis and it is accelerated in the presence of chronic hepatitis C virus (HCV). It is clinically sound that HCV eradication may stop the progression of cirrhosis but is unknown whether ongoing alcohol consumptions may counteract the beneficial effect of sustained virological response (SVR).


REFERENCES

  1. Monto A, Patel K, Bostrom A, Pianko S, Pockros P, McHutchison JG, Wright TL. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology 2004; 39: 826-34.

  2. Westin J, Lagging LM, Spak F, Aires N, Svensson E, Lindh M, Dhillon AP, et al. Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection. J Viral Hepat 2002; 9: 235-41.

  3. Wiley TE, McCarthy M, Breidi L, McCarthy M, Layden TJ. Impact of alcohol on the histological and clinical progression of hepatitis C infection. Hepatology 1998; 28: 805-9.

  4. Vandenbulcke H, Moreno C, Colle I, Knebel JF, Francque S, Sersté T, George C, et al. Alcohol intake increases the risk of HCC in hepatitis C virus-related compensated cirrhosis: A prospective study. J Hepatol 2016; 65: 543-51.

  5. Devaux M, Sassi F. Social disparities in hazardous alcohol use: self-report bias may lead to incorrect estimates. Eur J Public Health 2016; 26: 129-34.

  6. Bellentani S, Tiribelli C. The spectrum of liver disease in the general population: lesson from the Dionysos study. J Hepatol 2001; 35: 531-7.

  7. Epstein EE, Kahler CW, McCrady BS, Lewis KD, Lewis S. An empirical classification of drinking patterns among alcoholics: binge, episodic, sporadic, and steady. Addict Behav 1995; 20: 23-41.

  8. Poynard T, Degott C, Munoz C, Lebrec D. Relationship between degree of portal hypertension and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic hepatitis on portal hypertension. Dig Dis Sci 1987; 32: 337-43.

  9. Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 2007; 165: 710-18.

  10. Moons KG, Altman DG, Reitsma JB, Ioannidis JP, Macaskill P, Steyerberg EW, Vickers AJ, et al. Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration. Ann Intern Med 2015; 162: W1-73.

  11. Ganne-Carrié N, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, et al. Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir). Hepatology 2016; 64: 1136-47.

  12. van der Meer AJ, Feld JJ, Hofer H, Almasio PL, Calvaruso V, Fernández-Rodríguez CM, Aleman S, et al. Risk of cirrhosisrelated complications in patients with advanced fibrosis following hepatitis C virus eradication. J Hepatol 2016; Oct 22. pii: S0168-827830582-7. doi: 10.1016/j.jhep.2016.10.017. [Epub ahead of print] PubMed PMID: 27780714.

  13. Sobell LC, Sobell MB. Alcohol Consumption Measures. Available at: http://pubs niaaa nih gov/publications/AssessingAlcohol/ sobell pdf 2003 Oct;Accessed on November 20th, 2016.




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