Other malignant neoplasm incidence in patients with nephrectomy for renal cell carcinoma

Manuel Barrera; Pedro Palacios; Fernando León; Víctor Figueroa; Guillermo Feria; Fernando Gabilondo

2005, Number 3

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Rev Mex Urol 2005; 65 (3)

Other malignant neoplasm incidence in patients with nephrectomy for renal cell carcinoma

Barrera M, Palacios P, León F, Figueroa V, Feria G, Gabilondo F

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Language: Spanish
References: 13
Page: 177-182
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ABSTRACT

Objective. To determine the association between renal cell carcinoma and the risk to develop other primary malignant neoplasm. Material and methods. We analyzed 132 patient retrospectively that were treated with nephectomy for the diagnosis of primary renal cell carcinoma between the period of 1987 and 2004. The frequency of other primary malignancies was classified as previous, simultaneous and subsequent. The observed result in our series were compared to those expected according to the SEER review 2001 (USA) to determine if the patients with renal cell carcinoma have an increased risk to develop another malignant neoplasm during a 60.4 months follow-up period. Results/.v Other primary neoplasm were present in 19 patient (14.4%) being 5 (26.3%) Previous, 3 (15.7%) simultaneous and 11 (57.8%) subsequent. The most frequent neoplasm found in males were prostate (3), bladder (3) and in female were breast (2), skin (2) and cervix carcinoma (2). Three patients had more than one neoplasm (2.2%). Other neoplasm found were Hodgkin’s lymphoma (1), non-Hodgkin lymphoma (1) gastric adenocarcinoma (1), colon adenocarcinoma (1), biliar duct carcinoma (1), chronic granulocytic leukaemia (1) and multiform grioblastoma (1). Comparing the observed number with the expected number adjusted to age and gender there was an increased frequency of bladder cancer in males and Hodgkin’s lymphoma and chronic granulocitica leukaemia en females (p = ‹ 0.05). Conclusions. Globally there were other primary neoplasm in 14.4% of the patients. These patients present more frequently other malignant neoplasm compared to a general population sample. The majority of the tumors were subsequent. There is a distinct distribution of the neoplasm by gender. In males bladder cancer was more frequent than expected and in females were Hodgkin’s lymphoma and chronic granulicit leukaemia.

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