2016, Number 6
<< Back Next >>
Ann Hepatol 2016; 15 (6)
Estimated time from clinical presentation to the development of cirrhosis in non-cirrhotic adult patients with non-alcoholic fatty liver disease
Minuk GY, Sanders J, O’Brien M, Uhanova J
Language: English
References: 6
Page: 944-945
PDF size: 94.44 Kb.
Text Extraction
Dear Editor:
The natural history of non-alcoholic fatty liver disease
(NAFLD) has yet to be fully defined. In the few relevant
studies reported to date, repeat liver biopsies were performed
in highly selected, predominantly non-alcoholic
steatohepatitis (NASH) patients who may not reflect the
general NAFLD population. Although newly developed,
non-invasive means of documenting hepatic fibrosis will
play an important role in providing natural history data,
prospective studies implementing these techniques will
take years and likely decades to complete.
REFERENCES
Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-85.
Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004; 40: 820-6.
Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005; 42: 132-8.
Mahady SE, George J. Management of nonalcoholic steatohepatitis: an evidence-based approach. Clin Liver Dis 2012; 16: 631-45.
Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-62.
Williams AL, Hoofnagle JH. Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis. Gastroenterology 1988; 95: 734-9.