2016, Number 1
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Med Sur 2016; 23 (1)
Epidemiology of chronic autoimmune liver disease: A histopathological study in third-level hospital in Mexico City
Valdivia-Correa B, Chablé-Montero F, Uribe M, Méndez-Sánchez N
Language: English
References: 20
Page: 43-48
PDF size: 123.37 Kb.
ABSTRACT
Background. Autoimmune liver diseases (AILD) comprise a heterogeneous
group. The relative frequencies of AILD have not been
studied properly. Epidemiological studies in Mexico are limited.
Objective. The aim was to determine the prevalence of AILD
histopathology in a group of Mexican patients.
Material and
methods. We retrospectively examined 785 liver biopsy specimens.
Medical records were analyzed in order to recollect data.
Results. Sixty-seven patients showed compatible characteristics
with AILD; 56 were women (83.6%) and 11 men (16.4%). The
results showed that the prevalence of AILD during this period was
8.5%. The most frequent associated comorbidity was other autoimmune
diseases (20.89%). The main cause of cirrhosis in the female
group was AIH (100%), and in the male group PBC (42%).
Conclusions.
This study shows a probable increasing tendency in the
prevalence of AILD, however, it is important to collect more epidemiological
information in order to truly define the prevalence.
REFERENCES
Bunchorntavakal C, Reddy KR. Diagnosis and management of Overlap Syndromes. Clin Liver Dis 2015; 19: 81-97 [PubMed: 25454298].
Karlsen TH, Chung BK. Genetic risk and the development of autoimmune liver disease. Dig Dis 2015; 33: 13-24 [PubMed: 26641277].
Méndez Sánchez N, Villa AR, Chávez Tapia NC, Ponciano Rodríguez G, Almeda Valdés P, González D, Uribe M. Trends in liver disease prevalence in Mexico from 2005 to 2050 through mortality data. Ann Hepatol 2005; 4: 52-55 [PubMed: 15798662].
Méndez Sánchez N, Aguilar Ramírez JR, Reyes A, Dehesa M, Juárez A, Castańeda B, Sánchez Ávila F, et al. Etiology of liver cirrhosis in Mexico. Ann of Hepatol 2004; 3: 30-33 [PubMed: 15118577].
Jepsen P, Gronbaek L, Vilstrup H. Worldwide incidence of autoimmune liver disease. Dig Dis 2015; 33: 2-12 [PubMed: 26641102].
Metcalf J, James O. The Geoepidemiology of Primary Biliary Cirrhosis. Semin Liver Dis 1997; 17: 13-22 [PubMed: 9089907].
Whalley S, Puvanachandra P, Desai A, Kennedy H. Hepatology outpatient service provision in secondary care: a study of liver disease incidence and resource costs. Clin Med (Lond) 2007; 7: 119-24 [PubMed: 17491498].
Hurlburt KJ, McMahon BJ, Deubner H, Hsu Trawinski B, Williams JL, Kowdley KV. Prevalence of autoimmune liver disease in Alaska natives. Am J Gastroenterol 2002; 97: 2402-7 [PubMed: 12358264].
Invernizzi P, Lleo A, Podda M. Interpreting serological tests in diagnosing autoimmune liver diseases. Semin Liver Dis 2007; 27: 161-72 [PubMed: 17520516].
Rockey DC, Caldwell SH, Goodman ZD, Nelson RC, Smith AD, American Association for the Study of Liver Diseases. Liver Biopsy. Hepatology 2009; 49: 1017-44 [PubMed: 19243014].
Tianiakos DG, Brain JG, Bury YA. Role of histopathology in autoimmune hepatitis. Dig Dis 2015; 33: 53-64 [PubMed: 26642062].
Corpechot C, Carrat F, Bahr A, Chrétien Y, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 128: 297-303 [PubMed: 15685541].
Amarapurkar D, Amarapurkar A. Indications of liver biopsy in the era of noninvasive assessment of liver fibrosis. J Clin Exp Hepatol 2015; 5: 314-9 [PubMed: 26900273].
James OF, Bhopal R, Howel D, Gray J, Burt AD, Metcalf JV. Primary biliary cirrhosis once rare, now common in the United Kingdom? Hepatology 1999; 30: 390-4 [PubMed: 10421645].
Gronbaek L, Vilstrup H, Jepsen P. Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis and causes of death. A nationwide registry-based cohort study. J Hepatol 2014; 60: 612- 17 [PubMed: 24326217].
Terraciano LM, Patzina RA, Lehman FS, Tornillo L, Cathomas G, Mhawech P, Vecchione R, et al. A spectrum of histopathologic findings in autoimmune liver disease. Am J Clin Pathol 2000; 114: 705-11 [PubMed: 11068543].
Patterson AL, Allison ME, Brais R, Davies SE. Any value in a specialist review of liver biopsies? Conclusions of a four-year review. Histopathology 2016, 69: 315-21 [PubMed: 26826338].
Spycher C, Zimmermann A, Reichen J. The diagnostic value of liver biopsy. BMC Gastroenterol 2001; 1: 1-6 [PubMed: 11707153].
Zen Y, Harada K, Sasaki M, Tsuneyama K, Matsui K, Haratake J, Sakisaka S, et al. Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts. J Gastroenterol 2005, 40: 164-70 [PubMed: 15770400].
Washington MK. Autoimmune liver disease: overlap and outliers. Mod Pathol 2007; 20: S15-S30 [PubMed: 17486048].