Rafael-Alemán B, Carsi-Bocanegra EE, Suárez-Cárdenas M, Robledo-Galván AE

Language: Spanish
References: 25
Page: 117-126
PDF size: 172.13 Kb.

ABSTRACT

Background: Bacterial neonatal infections are a major cause of morbidity and mortality. used antimicrobial drugs frequently their rational use, implies that professionals prescribe a well chosen medication, appropriate dose, during the appropriate time and at the lowest cost, taking into account effectiveness and adverse effects.
Objetive: To understand and to analyze antibiotic use at the neonatal intensive care unit of the National Medical Center “20 de Noviembre” ISSSTE, and to evaluate whether the use of these antibiotics is rational or irrational.
Material and Method: retrospective and descriptive study in the Intensive Care Unit Neonatal CMN November 20, ISSSTE, and representative sample size was calculated by the formula Enric Mateu being 93 records reviewed of newborns hospitalized. The most common indication for antibiotics and the initial justification was assessed, if doses of antibiotics were adjusted according to gestational age, days of life and dosing interval. Was assessed too if the use was indicated by the presence of clinical data, inflammatory response syndrome (SIRS) or paraclinical data, or by the association of one or more of these. In this study is presented the characteristics of antibiotic use in therapeutic form (part I) and second publication prophylactic antibiotic use (Part II)
Results: 93 records were reviewed; the therapeutic indication was 55.9% in the prophylactic WAS 44.1. % .The therapeutic use was initiated BY clinical suspicion of infection 36.5%; paraclinical data by 28.8%; by 19.2% clinical and laboratory data; 7.7% by localized infection by systemic inflammatory response syndrome (SIRS) 3.9%, and SIRS and clinical data and paraclinical infection 3.9%
Conclusion: The use of antibiotics for therapeutic is rational for early sepsis and does not meet all the criteria for rational use in case of late sepsis

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