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2016, Number 3

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Dermatología Cosmética, Médica y Quirúrgica 2016; 14 (3)

Rosai-Dorfman Cutaneous Pure Disease: Two Cases Report

Santiago RT, Quintos RAI, Rivera GMI, Quintal RMJ, Pulido DN

Language: Spanish
References: 18
Page: 209-212
PDF size: 173.87 Kb.


ABSTRACT

Sinus histiocytosis or Rosai-Dorfman with massive lymphadenophaty is a pseudo-lymphomatous disorder, benign, self-limiting, of unknown etiology, characterized by cervical lymphadenophaty and neutrophilic leukocytosis. The only skin afection is observed in 3% of cases. It presentes two cases compatible with Rosai-Dorfman disease cutaneous pure (erdcp) diagnosed in La Raza National Medical Center, in the period 2011-2014. The cases of two women in the fifth and sixth decade of life with multiple nodular cutaneous manifestations of spontaneous and painful appearance with histopathologic finding consistent with the presence of histiocytic infiltrate, emperipolesis and positive immunohistochemistry for cd3, cd68, s100 and present light Kappa and Lambda chains. Even though there is no standardized treatment, the first patient was treated with systemic steroids while in the second case it was decided chemotherapy treatment with chop (cyclophosphamide, doxorubicin, vincristine, prednisone) scheme, featuring multiple side effects. Both treatment with poor response. We present this two cases because of the few reports in the literature and little knowledge of this entity.


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