2016, Number 4
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Rev Cubana Pediatr 2016; 88 (4)
Clinical manifestations and etiologies related to febrile seizures
Portuondo BE
Language: Spanish
References: 44
Page: 428-440
PDF size: 202.22 Kb.
ABSTRACT
Introduction: febrile seizures are one of the most common causes of admission to
emergency services and of appointments with the neuropediatricians.
Objective: to describe the clinical manifestations and the etiology related to first febrile seizure on hospital discharge.
Methods: retrospective and observational study of 327 children seen at the
emergency service of Centro Habana pediatric hospital from January 2005 to
December 2013. The sample included 313 patients (185 girls and 128 boys)
diagnosed with first complex or simple febrile seizures whereas 14 children with other
paroxistic events were excluded. The children were distributed into three age groups
and the age of the first febrile seizure was compared with the clinical diagnosis on
hospital discharge. Symptoms, clinical signs and analytical exams on admission to the
service were all registered.
Results: one-four years old group and males predominated (74.1 %). The simple
febrile seizures prevailed in 85,9 % of cases and in older than one year-old children
with 69 % (p ‹ 0.05). The febrile seizures appeared in the first 24 hours of fever in 77.2 % of children (20.1 % in the first hour). In 89 children (28.4 %), fever was the
only symptom or initial sign related to the first febrile seizure; 174 (55.6 %) showed
symptoms and signs in the upper respiratory tract whereas the most common
infections occurred in this tract (62.2 %). Viral etiologies (68.6 %) prevailed over the
bacterial ones (27 %). Cerebrospinal fluid tests were performed in all the children
with no evidence of infection in the central nervous system.
Conclusions: simple febrile seizures related to viral infections are the most common ones.
REFERENCES
Chung B, Wong V. Relationship between five common viruses and febrile seizurein children. Arch Dis Child. 2007;92:589-93.
Mewasingh LD. Febrile seizures. BJM Clinical Evidence. 2008;05:324-33.
American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Febrile Seizures. Practice parameter: long-termtreatment of the child with simple febrile seizures. Pediatrics. 1999;103:1307-9.
Moreno de Flagge N. Crisis febriles simples y complejas, epilepsia generalizada con crisis febriles plus, FIRES y nuevos síndromes. Medicina (Bs Aires). 2013;73(supl 1):63-70.
Nakayama J. Progress in searching for the febrile seizures susceptibility gene. Brain Rev. 2009;31:359.
Heida JG, Mosché SL, Pittman QJ. The role of interleukin 1-beta in febrile seizures. Brain Rev. 2009;31:388.
Choy M, Dubé CM, Ehrengruber M, Baram TZ. Inflammatory processes, febrile seizures and subsequent epileptogenesis. Current Review. American Epilepsy Society. Epilepsy Currents. 2014;14(1):15-22.
Virta M, Hurme M, Helminen M. Increased plasma levels of pro- and antiinflammatory cytokines in patients with febrile seizures. Epilepsia. 2002(43):920-3.
Konn-Concarica G, Rino P, Zlotogora A, Boto A, Fustiñana A, Catella A, Caraballo RH. Tratamiento de las convulsiones febriles en el departamento de emergencias. Medicina Infantil. Pediatría Práctica. 2011;XVIII(3):285-90.
Caraballo RH, Fejerman N. Síndrome de convulsiones febriles benignas y convulsiones febriles con factores de riesgo. Tratamiento de las Epilepsias. Buenos Aires: Editorial Médica Panamericana; 2009. p. 134-5.
Jones T, Jacobsen SJ. Childhood febrile seizures: overview and implications. INT J MedScl. 2007;4(2):110-4.
Cancho-CandelaR, Peña-Valenceja A, Alcalde-Martin C, Ayuso-Fernández M, Medrano-Sánchez O, Ochoa-Sangrador C. Convulsiones benignas durante gastroenteritis leve por Rotavirus. Rev Neurol. 2009;49(5):230-3.
Valladares SP, Solórzano E, Gutíerrez MJ, Verita SJA. Epilepsia posvacunal, presentación de 4 casos. Boletín Médico de Hospital Infantil de México. 2006;63(supl):102-3.
Millichap JG, Cowler JA. Management of febrile seizures: survey of current practice and usage. Pediatr Neurol. 2009;7:243-8.
Sadleir LG, Scheffer IE. Febrile seizures. Clinical Review. BJM. 2007;334:307-11.
Chin RFM, Neville BG, Scott RC. Meningitis is a common cause of convulsive status Epilepticus with fever. Arch Dis Child. 2005;90:66-9.
Martinez-Cayuela E, Herraiz-Martínez M, Villacieros-Hernandez L, Ceán-Cabrera L, Martinez-Salcedo E, Alarcón-Martínez H, et al. Crisis febriles complejas: ¿Debemos cambiar nuestro modo de actuación? Rev Neurol. 2014;59:449-58.
Boyle DA, Sturm JJ. Clinical factors associated with invasive testing and imaging in patients with complex febrile seizures. Pediatr Emerg Care. 2013;29:430-4.
Consensus development panel (1980). Febrile seizures: long-term management of children with fever-associated seizures. Paediatrics. 1980;66:1009-12.
Camfield PR, Camfield CS, Scheffer IE, Marini C. Febrile seizures and genetic epilepsy with febrile seizures plus (GESF +). In: Chapter 13. Boreau M, Genton P, Dravet C, Delgado-Escueta A, Tassinari CA, Thomas P, eds. Epileptic syndromes in Infancy-childhood and adolescence. 5ta. ed). England: John Libbey Eurotext Ltd.; 2012. p. 175-87.
Pizarro ME, Borth H, Celia de la HC, Villarroel del PL, Cerda LJ, Mesa T, et al. Recurrencia de crisis febriles en una población chilena. Rev Chil Pediatr. 2008;79(5):488-94.
Steering committee on quality improvement and management subcommittee of febrile seizures: clinical practice guideline for the long-term management of child with simple febrile seizures. Pediatrics. 2008;121:1282-6.
Graves RC, Oehler K, Tingle LE. Febrile seizures: Risk, evaluation and prognosis. Am Fam Physician. 2012;85:149-53.
Berzosa-López R, Ramos-Fernández JM, Martinez-Antón J, Espinoza-Sánchez MG, Urda-Cardona A. Crisis febriles complejas. Estudio de patología asociada y utilidad de pruebas complementarias. An Pediatr (Barc). 2014;80:365-9.
Deyá-Martinez A, Claret-Teurel G, Fernández-Santervás Y, Trenchs-Sainz de la Maza V, Gonzáles-Álvarez V, Luaces-Cubells C. ¿Se debe ser más intervencionista en urgencias con las convulsiones febriles atípicas? Experiencia de un hospital terciario durante 3 años. Rev Neurol. 2013;56:353-8.
Mastrangelo M, Midvulla F, Moretti C. Actual insights into the clinical management of febrile seizures. Eur J Pediatr. 2014;173:977-82.
Hardasmalani MD, Saber M. Yield of diagnostic studies in children presenting with complex febrile seizures. Pediatr Emerg Care. 2012;28:789-91.
Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of "febrile seizures": Ad Hoc Task Force of LICE guidelines commission. Epilepsia. 2009;50(suppl 1):2-6.
Lesterohald M, Pedersen MG, Ostergaard JR, Pedersen CB, Olsen J, Cristensen J. Death in children with febrile seizures: a population based cohort study. Lancet. 2008;9:457-63.
Ripoll Lozano A, Santos Borbujo J. Convulsiones febriles, protocolo diagnósticoterapéutico. Neuropediatría Bol Pediatr. 2000;40:68-71.
Hannah CK. Sudden Death, Febrile Seizures, and Hippocampal and Temporal Lobe Maldevelopment in Toddlers: A New Entity. Pediatr Dev Pathol. 2009;12(6):455-63.
Berzosa CR, Ramos Fernández JM, Martínez Antón J, Espinoza Fernández MG, Urda Cardona A. Complex febrile seizures: study of the associated pathology and practical use complementary test. An Pediatr Barc. 2014;80(6):365-9.
Delpishen A, Veisani Y, Sayehmiri K, Fayyazi A. Febrile seizures: etiology, prevalence and geographical variation. Iran J Child Neurol. 2014;8(3):30-7.
Wong V. Acute gastroenteritis-related encephalopathy. J Child Neurol. 2001;16(2):906-10.
Shi X, Lin Z, Ye X, Hu Y, Zieng F, Huh H. An epidemiological survey of febrile convulsions among pupils in the Wenzhou region. Zhonggvo Dang Daierkezazhi. 2012;14(2):128-30.
Saju Chung S. Febrile seizures, review article. Korean J Pediatr. 2014;57(9):389-95.
American academy of pediatrics. Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. Pediatrics. 1996;97:769-75.
Guidelines & Protocols Advisory Committee. Febrile seizures. Ann Emerg Med. 2003;41:215-22.
Patel AD, Vidaurre J. Complex febrile seizures: a practical guide to evaluation and treatment. J Child Neurol. 2013;28:762-7.
Srinivasan J, Wallace K, Scheffer I. Febrile seizures. Australian Family Physician. 2005;34(12):1021-36.
Millichap JG, Millichap JJ. Influenza virus and febrile convulsions. J Infect Dis. 2004;189:564-5.
Rojas-Rojas CF, Darío-Flóres I, Sierra JM, Cornejo-Ochoa W. Incidencia de meningitis en lactantes con crisis febriles simples. Experiencia en un hospital de 3er. nivel. Acta Neuro Colomb. 2013;29:229-30.
Kimia A, Ben-Joseph E, Prabhu S, Rudloe T, Lapraro A, Sarlo D, et al. Yield of emergent neuroimaging among children with a first complex febrile seizure. Pediatric Emerg Care. 2012;28:316-21.
Batra P, Gupta S, Gomber S, Saha A. Predictors of meningitis in children presenting with first febrile seizures. Pediatric Neurol. 2011;44:34-5.