medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2015, Number 2

<< Back

Arch Neurocien 2015; 20 (2)

Primitive cerebral melanoma

Vargas-Olguín E, Rejón-Pérez JD, Alcántara-Gómez LA, Uribe-Olalde JS, Flores-Vázquez M, Robledo-Moreno E, Reyes-Velasco E

Language: Spanish
References: 12
Page: 161-165
PDF size: 392.33 Kb.


ABSTRACT

Statistically, intracranial malignant melanoma in the population is approximately 0.005 cases / 100 000, with a prevalence towards the male population. Principles have been described to the approach for diagnosis and surgical oncologic treatments. We present a case report of a man 39-year-old, with evolution characterized by headache, lateralization gait, dysmetria, dysdiadochokinesia, truncal ataxia and Romberg. Starting the diagnostic protocol is identified by MRI the presence of a lesion in the right posterior fossa, with significant edema. That is why it is scheduled for surgical management, achieving total resection of the lesion and subsequent report by the Clinical Pathology Service as melanoma. Immunohistochemistry tests being positive S100 and HMB 45 in the extension studies for ophthalmology, dermatology and gastroenterology with conducting Panendoscopy was not possible to find another source of tumor growth. The study of positron emission tomography showed no positivity across the previously known save intracranial growth. Conclusion: patterns of diagnosis of melanoma of the central nervous system make it essential to thoroughly investigate possible sites of origin and rule out metastatic lesions; regarding the management, consider total ablation wherever possible and the use of aggregate cancer therapy.


REFERENCES

  1. Bergdahl L, Boquist L, Liliequist B, Yhulin C, Tovi D. Primary malignant melanoma of the central nervous system. A report of 10 cases. Ac Neurochirurg 1972;26:139-49.

  2. Wadasadawa T, Trivedi S, Gupta T, Epari S, Jalali R. The diagnostic dilemma of primar y central nervous system melanoma. J Clin Neurosc 2010;17:1014-7.

  3. Castro G, Soffietti R, Brdac G, Boldorini R. Primitive cerebral melanoma: case report and review of the literature. Surg Neurol 2001;55:163-8.

  4. Rovira V, Riesgo P, Piquer J, Llacer J, Cortés F, Cabanes J. Melanoma maligno primario de fosa posterior: caso clínico. Neurocirugía 2000; 11:446-9.

  5. Nicolades P, Newton R, Kelsey A. Primary malignant melanoma of meninges: atypical presentation of subacute meningitis. Pediatr Neurol 1995; 12: 172-4.

  6. Wang J, Gou Z, Jang Y, Zhang S, Xing D. Microsurgery for treatment of primary malignant intracranial melanoma: a surgical series and literatura review. Eur J Surg Oncol 2013:1-10.

  7. Arantes M, Ferreira A, Romao H, Meireles P, Garcia R, Honavar M, et al. Primary pineal malignant melanoma: Case report and literature review. Clin Neurol Neurosurg 2011;113:59-64.

  8. López J, Diaz F, Soult J, Muñoz M, Barriga R. Primar y leptomeningeal melanoma in a Child. Pediatr Neurol 2001;24:390-2.

  9. Hayward RD. Malignant melanoma and the cerebral nervous system. A guided for classification based on the clinical findings. J Neurol Neurosurg Psychiatry 1976;526-30.

  10. Bafaloukos D, Gogas H. The treatment of brain metastases in melanoma patients. Cancer treatment reviews 2004;30,515-20.

  11. Liubinas S, Maartens N, Drummond K. Primary melanocytic neoplasms of the central nervous system. J Clin Neuroscience 2010;(17):1227-32.

  12. Zimmer C, Gottschalk J, Goebel S, Cervos J. Melanomaassociated antigens in tumors of the nervous system: an inmunohistochemical study with the monoclonal antibody HMB-45. Virchows Archiv A Pathol Anat 1992;420:121-5.




2020     |     www.medigraphic.com