Ardila MCM, Bedoya GJ, Guzmán ZIC

Language: Spanish
References: 18
Page: 470-476
PDF size: 587.67 Kb.

ABSTRACT

Background: serum amyloid A protein is produced in response to the cytokines released by monocytes and macrophages after an acute-phase stimulus such as infection.
Objective: to determine the serum levels of amyloid A protein and its association with patients diagnosed with chronic periodontal disease.
Methods: a cross-sectional observational study was conducted. The universe was composed of 80 pa-tients with chronic periodontitis and 28 people without periodontal affections as a control group. Diagnosis of chronic periodontal disease was based on criteria stated previously. All the participants answered a questionnaire related to sociodemographic characteristics. A clinical enzymatic trial was carried out to cal-culate the levels of pathological serum amyloid A.
Results: pathological levels of serum amyloid A were associated with periodontitis (p=0,002) and were correlated significantly with older age (r=2,42; p=0, 01). Nevertheless, logistic regression adjusted by age showed remarkable statistical association only with periodontal disease (OR=5,6; interval from 95 % 1,7-19).
Conclusions: probability of presenting pathological levels of serum amyloid A in patients with chronical periodontal disease is six times the one of the patients without this affection. That could me a risk factor for cardiovascular diseases.

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