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2016, Number 1

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Rev Cubana Hematol Inmunol Hemoter 2016; 32 (1)

Role of nadph oxidase system in the neutrophil extracelular Traps (NETs) formation

Vélez TGJ, Rocha AYC, Arias SAA, López QJÁ

Language: Spanish
References: 57
Page: 43-56
PDF size: 336.03 Kb.


ABSTRACT

Neutrophil extracellular traps (NETs) are structures mainly composed of chromatin and granule proteins that once released constitute a defense mechanism due to their ability to trap and destroy pathogen microorganisms. The process by which these structures are released is known as NETosis and in case this may lead to cell death is different to apoptosis and necrosis. Although all the molecular events involved in the formation of NETs are poorly understood, it is known that depending on the stimulus, reactive oxygen species (ROS) are essential to the chromatin decondensation and subsequent NETs formation.


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