2016, Number 620
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Rev Med Cos Cen 2016; 73 (620)
Síndrome de Zollinger-Ellison (ZES)
Urbina ME
Language: Spanish
References: 11
Page: 491-496
PDF size: 328.58 Kb.
ABSTRACT
Zollinger-Ellison syndrome
(ZES) is a condition
characterized by gastrinsecreting
tumors, responsible
for causing the formation
of multiple, refractory, and
recurrent peptic ulcers in
the duodenum. Two main
variants have been described,
sporadic and those found
in association with multiple
endocrine neoplasia-1 (MEN-
1). Biochemical serum
evaluation for elevated gastrin,
followed by radiological or
nuclear localization of the
primary lesion, is mandated
for establishing diagnosis. The
mainstays of treatment include
management of hypersecretory
state with medical suppression
of gastric acid production and
surgical resection of primary
tumor for the prevention of
malignant transformation
and metastatic complications.
Medical therapy with proton
pump inhibitors has virtually
eliminated the need for acidreducing
surgical procedures.
Reexcision of recurrent or
resection of metastatic disease
is a subject of controversy;
however, at the present time
aggressive cytoreductive
approach is favored.
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