2015, Number 4
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Med Sur 2015; 22 (4)
Amiodarone pulmonary toxicity
Bahena-López E, Bucio-Reta E, Bahena-López Jessica-Paola
Language: Spanish
References: 10
Page: 214-217
PDF size: 307.45 Kb.
ABSTRACT
Amiodarone-caused pulmonary toxicity (APT) is a well-known adverse
event of this medication, correlates more closely with the total
cumulative dose than with serum drug levels. APT can resemble
pulmonary infection, heartfailure, pulmonary thromboembolism or
restrictive pulmonary disease, the refore the diagnosis is difficult
and delayed in cases without strong clinical suspicion. It can present
as chronic interstitial pneumonitis, organizing pneumonia, acute
respiratory distress syndrome (ARDS) and solitary pulmonary mass.
It is diagnosed by exclusion, being the chest computerized tomography
a useful diagnostic tool. Discontinuation of amiodaroneisthe
primary the rapy, additionally for patients with symptomatic pulmonary
toxicity, systemics teroids may be useful.
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