medigraphic.com
ISSN 2007-4360 (Print)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2016, Number 2

<< Back Next >>

Rev Mex Periodontol 2016; 7 (2)

Matrix metalloproteinases in patients with periodontitis and diabetes mellitus

Gómez-Sandoval JR, Mariaud-Schmidt RP

Language: Spanish
References: 32
Page: 55-60
PDF size: 328.76 Kb.


ABSTRACT

Periodontitis is an inflammation of the supporting structures of the teeth, usually caused by specific microorganisms or groups of microorganisms, that results in the progressive destruction of the periodontal ligament and alveolar bone. In addition, periodontitis has an important relationship with chronic degenerative diseases, such as diabetes mellitus. There is evidence that in patients with diabetes mellitus, a decreased activity of polymorphonuclear leukocytes exists, as well as defects in apoptosis, formation of advanced glycosylation end products, continuous release of matrix metalloproteinases and reactive oxygen species, all of which contribute to the accelerated destruction of the periodontal tissues. Specifically, matrix metalloproteinases are extracellular proteases required in many processes related to cell development, tissue regeneration and some diseases such as cancer. Their physiological activity is to degrade the extracellular matrix proteins; when overexpressed, they increase their degradative activity, which induces tissue damage. Several authors have reported that matrix metalloproteinases, including matrix metalloproteinases-2, 3, 8 and 13, are present in the inflamed periodontal tissue, causing damage to it. In patients with diabetes and periodontitis, increased levels of matrix metalloproteinases-2, 8, 9 and 14 have been identified, regardless of periodontal inflammation. Detecting the presence of matrix metalloproteinases in individuals with periodontal disease and diabetes mellitus could represent an important biomarker of tissue damage.


REFERENCES

  1. Newman MG, Takei HH, Carranza FA. Periodontología clínica. 11.a edición. Buenos Aires, Argentina: Editorial Interamericana; 2014.

  2. Rioboo-Crespo M, Bascones A. Factores de riesgo de la enfermedad periodontal: factores genéticos. Avances en periodoncia e implantología oral. 2005; 17 (2): 69-77.

  3. Ximenez-Fyvie LA, Almaguer-Flores A, Jacobo-Soto V, Lara-Cordoba M, Sanchez-Vargas LO, Alcantara-Maruri E. Description of the subgingival microbiota of periodontally untreated Mexican subjects: chronic periodontitis and periodontal health. J Periodontol. 2006; 77 (3): 460-471.

  4. Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol. 2011; 38 (Suppl 11): 60-84.

  5. Janket SJ, Baird AE, Chuang SK, Jones JA. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95 (5): 559-569.

  6. Marchetti E, Monaco A, Procaccini L, Mummolo S, Gatto R, Tetè S et al. Periodontal disease: the influence of metabolic syndrome. Nutr Metab (Lond). 2012; 9 (1): 88.

  7. Acharya AB, Satyanarayan A, Thakur SL. Status of association studies linking diabetes mellitus and periodontal disease in India. Int J Diabetes Dev Ctries. 2010; 30 (2): 69-74.

  8. Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E et al. Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus. J Diabetes Investig. 2010; 1 (5): 212-228.

  9. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014; 37 (1): 81-90.

  10. Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care. 1993; 16 (1): 329-334.

  11. Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012; 55 (1): 21-31.

  12. Rajhans NS, Kohad RM, Chaudhari VG, Mhaske NH. A clinical study of the relationship between diabetes mellitus and periodontal disease. J Indian Soc Periodontol. 2011; 15 (4): 388-392.

  13. Shin DS, Park JW, Suh JY, Lee JM. The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus. J Periodontal Implant Sci. 2010; 40 (1): 33-38.

  14. Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000. 2007; 44: 127-153.

  15. Llambés F, Arias-Herrera S, Caffesse R. Relationship between diabetes and periodontal infection. World J Diabetes. 2015; 6 (7): 927-935.

  16. Cárdenas-León M, Díaz-Díaz E, Argüelles-Medina R, Sánchez-Canales P, Díaz-Sánchez V, Larrea F. Glycation and protein crosslinking in the diabetes and ageing pathogenesis. Rev Invest Clin. 2009; 61 (6): 505-520.

  17. Cascales M, Álvarez JA. Metaloproteinasas, matriz extracelular y cáncer. An R Acad Nac Farm. 2010; 76 (1): 59-84.

  18. Hardy DC, Ross JH, Schuyler CA, Leite RS, Slate EH, Huang Y. Matrix metalloproteinase-8 expression in periodontal tissues surgically removed from diabetic and non-diabetic patients with periodontal disease. J Clin Periodontol. 2012; 39 (3): 249-255.

  19. Bohórquez-Sierra JC. Metaloproteinasas de matriz: su implicación en las enfermedades vasculares periféricas. Angiología. 2006; 58 (4): 269-277.

  20. Negrato CA, Tarzia O, Jovanovič L, Chinellato LE. Periodontal disease and diabetes mellitus. J Appl Oral Sci. 2013; 21 (1): 1-12.

  21. Xu X, Xiao L, Xiao P, Yang S, Chen G, Liu F et al. A glimpse of matrix metalloproteinases in diabetic nephropathy. Curr Med Chem. 2014; 21 (28): 3244-3260.

  22. Nishikawa M, Yamaguchi Y, Yoshitake K, Saeki Y. Effects of TNFalpha and prostaglandin E2 on the expression of MMPs in human periodontal ligament fibroblasts. J Periodontal Res. 2002; 37 (3): 167-176.

  23. Ingman T, Apajalahti S, Rice D, Sorsa T. Gingival crevicular fluid, matrix metalloproteinases, and their bioactive regulators as potential adjunctive chair-side point-of-care biomarkers in orthodontic tooth movement. Seminars in Orthodontics. 2012; 18 (4): 270-277.

  24. Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SL, Grisi MF et al. Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol. 2010; 81 (3): 384-391.

  25. Collin HL, Sorsa T, Meurman JH, Niskanen L, Salo T, Rönkä H et al. Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus. J Periodontal Res. 2000; 35 (5): 259-265.

  26. Kumar MS, Vamsi G, Sripriya R, Sehgal PK. Expression of matrix metalloproteinases (MMP-8 and -9) in chronic periodontitis patients with and without diabetes mellitus. J Periodontol. 2006; 77 (11): 1803-1808.

  27. Kim JB, Jung MH, Cho JY, Park JW, Suh JY, Lee JM. The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis. J Periodontal Implant Sci. 2011; 41 (3): 109-116.

  28. Kim KA, Chung SB, Hawng EY, Noh SH, Song KH, Kim HH et al. Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients. J Periodontal Implant Sci. 2013; 43 (1): 24-29.

  29. Ramamurthy NS, Zebrowski EJ, Golub LM. Insulin reversal of alloxan-diabetes induced changes in gingival collagen metabolism of the rat. J Periodontal Res. 1974; 9 (3): 199-206.

  30. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med. 1993; 4 (2): 197-250.

  31. Van der Zee E, Everts V, Beertsen W. Cytokine-induced endogenous procollagenase stored in the extracellular matrix of soft connective tissue results in a burst of collagen breakdown following its activation. J Periodontal Res. 1996; 31 (7): 483-488.

  32. Death AK, Fisher EJ, McGrath KCY, Yue DK. High glucose alters matrix metalloproteinase expression in two key vascular cells: Potential impact on atherosclerosis in diabetes. Atherosclerosis. 2003; 68: 263-269.




2020     |     www.medigraphic.com