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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2016, Number 3

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An Med Asoc Med Hosp ABC 2016; 61 (3)

Pulmonary and osseous Langerhans’-cell histiocytosis in a female patient with autoimmune endocrinopathy: a case report. An inflammatory or neoplastic disease?

Cuevas CJE, Prieto SMP, Soria CD

Language: Spanish
References: 13
Page: 215-220
PDF size: 480.22 Kb.


ABSTRACT

Pulmonary Langerhans’-cell histiocytosis is a rare interstitial lung disease strongly associated with cigarette smoking. We present the case of a 48-year-old woman with type 1 diabetes, Hashimoto’s thyroiditis, and active cigarette smoking, who was admitted due to a community-acquired pneumonia that was unresponsive to antimicrobial treatment. A lung computed tomography scan showed multiple cysts and millimetric nodules with surrounding ground-glass opacities in upper lobes. Transbronchial lung samples and lytic left femur biopsies were performed, showing Langerhans-cell proliferation. Steroid treatment and smoking cessation counseling were started, showing a significant response. This case of a limited disease in an adult with an adequate response to smoking cessation and immunomodulator treatment suggests the pathogenesis does not involve a clonal proliferation, but rather an inflammatory disease.


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