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2016, Number 2

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Rev Cubana Plant Med 2016; 21 (2)

Antidepressant activity of Kielmeyera Rubriflora Cambes (Pau Santo) ethanolic extract on mice

Becheleni PA, Stuckert SSR, Gregório LE, Fernandes FSC

Language: Portugués
References: 38
Page: 181-195
PDF size: 168.41 Kb.


ABSTRACT

Introduction: The Kielmeyera rubriflora Cambess, belonging to the Clusiaceae family, is a native to the Vale do Jequitinhonha in Minas Gerais in Brazil, where it is used in folk medicine. It is popularly known as Pau Santo, Rosa do Campo, Flor de Santa Rita and Rosa do Cerrado. However, so far there are no data available in the literature on pharmacological studies regarding this species. The Kielmeyera coriácea is also a native plant in the region and there are already studies revealing its antidepressant action.
Objective: To evaluate the antidepressant action of the crude extract fron the aerial parts of K. rubriflora in mice.
Method: The crude extract from the aerial parts was administered v.o. at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg in albino Swiss, male mice, between 9 and 13 weeks of age, weighing between 29 and 43 g. In order to the investigation of antidepressant effects, the behavioral pharmacological screening (acute administration), forced swimming (chronic administration) and tail suspension (chronic administration) tests were performed.
Results: In the behavioral pharmacological screening were detected central nervous system depression effects with the dose of 100mg/kg and central nervous system stimulation with the doses of 250 and 500 mg/kg. In the tail suspension test, a dosedependent, but not significant, decrease in the immobility time was observed. In the forced swimming test a significantly lower immobility time was observed at all doses investigated, suggesting an antidepressant activity, especially at a dose of 100 mg/kg.
Conclusion: The results suggests an antidepressant action of the crude extract fron the aerial parts of K. rubriflora.


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