medigraphic.com
ISSN 1025-0298 (Electronic)
ISSN 1025-028X (Print)

2016, Number 2

<< Back

VacciMonitor 2016; 25 (2)

Immune adjuvant activity of the olive, soybean and corn oils

Marinho SAC, Freitas-Mota E, Guerra JL, Albuquerque D, Aragão ME, Sousa Nunes-Pinheiro DC, Silva-Lima MG, Fernandes-Melo D

Language: English
References: 20
Page: 55-59
PDF size: 46.51 Kb.


ABSTRACT

In the last half of the century, a large amount of substances has been used as immune adjuvant. The immune adjuvant effect of olive, soybean and corn oils in Swiss mice immunized with ovalbumin (OVA) plus aluminum hydroxide or emulsified in Marcol, soybean, olive or corn oils was evaluated through the OVA-specific antibodies determined by ELISA and Passive Cutaneous Anaphylaxis. In this work the comparison of the intensity of the immune response was established by the Bayesian analysis. The adjuvant effect of the vegetable oils was shown to be more effective than aluminium hydroxide. Regarding to OVA-specific IgE synthesis, olive oil had the slowest adjuvant effect of the three vegetable oils. Accordingly, olive oil was the most convenient among the vegetable oils to be used as immune adjuvant, since it stimulated a higher production of OVA-specific Ig and lower levels of anti-OVA IgE.


REFERENCES

  1. Vogel FR. Adjuvants in perspective. Developments in Biological Standardization 1998;92:241-8.

  2. Engers H, Kieny MP, Malhotra P, Pink JR. Third meeting on Novel Adjuvants Currently in or Close to Clinical Testing World Health Organization – Organisation Mondiale de la Santé, Fondation Merieux, Annecy, France. Vaccine 2003;21:3503-24.

  3. Brito LA, Malyala P, O’Hagan DT. Vaccine adjuvant formulations: A pharmaceutical perspective. Seminars in Immunology 2013;25:130-45.

  4. Barnett PV, Pullen L, Williams L, Doel TR. International bank for Foot-and-mouth disease vaccine: assessment of Montanide ISA 25 and ISA 206, two commercially available adjuvants. Vaccine 1996;14:1187-98.

  5. Cox JC, Coulter AR. Adjuvants – a classification and review of their modes of action. Vaccine 1997;15:248-56.

  6. Audibert FM, Lise LD. Adjuvants: current status, clinical perspectives and future prospects. Immunology Today 1993;14:281-4.

  7. Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, et al. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nature Immunology 2002;2:397-402.

  8. Claassen E, Leeuw W, Greeve P, Hendriksen C, Boersma W. Freund’s complete adjuvant: an effective but disagreeable formula. Research in Immunology 1992;143:478-83.

  9. Allison AC, Byars NE. Immunological Adjuvants: desirable properties and side effects. Molecular Immunology 1991;28:279-84.

  10. Brugh M, Stone HD, Lupton HW. Comparison of inactivated Newcastle disease viral vaccines containing different emulsion adjuvants. American Journal of Veterinary Research 1983;44:72-5.

  11. Kimura J, Nariuchi H, Watanabe T, Matuhasi T, Okayasu I, Hatakeyama S. Studies on the adjuvant effect of water-in-oil-in-water (w/o/w) emulsion of sesame oil. 1. Enhanced and persistent antibody formation by antigen incorporated into the water-in-oil-in-water emulsion. The Japanese Journal of Experimental Medicine 1978;48:149-54.

  12. Basketter D, Kimber I. Olive oil: suitability for use as a vehicle in the local lymph node assay. Contact Dermatitis 1996;35:190-1.

  13. Crevel RWR, Kerkhoff MA, Koning MM. Allergenicity of refined vegetable oils. Food and Chemical Toxicology 2000;38:385-93.

  14. Wolfinger RD, Kass RE. Nonconjugated Bayesian analysis of variance components models. Biometrics 2000;56:268-77.

  15. Sartor ITM, Colodel EM, Albuquerque D. Adjuvant activity of rice oil on the immune response to ovalbumin. VacciMonitor 2011;20(2):1-5.

  16. Mota I, Wong D. Homologous and Heterologous Passive Cutaneous Anaphylactic Activity of Mouse anti-sera During the Course of Immunization. Life Science 1969;8:813-20.

  17. Prouvost-Danon A, Mouton D, Abadie A, Biozzi G. Genetic regulation of IgE and agglutinating antibody synthesis in lines of mice selected for high and low immune responsiveness. European Journal of Immunology 1977;7:342-8.

  18. Moreto, E. Tecnologia de óleos e gorduras. São Paulo: Ed. Varela; 1998.

  19. Prouvost-Danon A, Binaghi R, Rochas S, Boussac-Aron Y. Immunochemical identification of mouse IgE. Immunology 1972;23:481-91.

  20. Brewer JM, Conacher M, Gaffney M, Douglas M, Bluethmann H, Alexander J. Neither interleukin-6 nor signaling via tumor necrosis factor receptor-1 contribute to the adjuvant activity of Alum and Freund’s adjuvant. Immunology 1998;93:41-8.




2020     |     www.medigraphic.com