Ochoa-Azze R, García-Imia L

Language: Spanish
References: 16
Page: 43-48
PDF size: 49.25 Kb.

ABSTRACT

Vaccines based on outer membrane vesicles of Neisseria meningitidis serogroup B strains have been questioned by some researchers, who limit its effectiveness to the vaccine strain. VA-MENGOC-BC^® is a meningococcal vaccine based on this technology. A meta-analysis of independent studies in different epidemiological contexts is used to assess the clinical effectiveness of the vaccine against heterologous serogroup B strains in several age groups. In this paper we provide evidence supporting its effectiveness against homologous and heterologous strains from different clonal complexes.

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