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Instituto Nacional de Neurología y Neurocirugía

2005, Number 3

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Arch Neurocien 2005; 10 (3)

Favorable effects of pyridoxine and folic acid supplementation shr-sp

Perez SC, Vianna LM

Language: English
References: 24
Page: 146-149
PDF size: 60.83 Kb.


ABSTRACT

Homocysteine has been associated to the stroke, which enhances the interest for the investigation about the role of vitamins involved on its metabolism. Stroke Prone rats were treated by pyridoxine and folic acid at doses correspondent to five, ten and twenty times their nutritional needs. The systolic blood pressure and general parameters were analyzed and compared to control group. The doses correspondents to 10 and 20 times RDA promoted a hypotensive effect, but doses correspondents to 5 times, did not. The treated animals at 190 days of age presented a significant reduction of systolic blood pressure: 204 ± 3mmHg when compared to control group: 230 ± 5mmHg. At seven months of age the animals under treatment did not present signs of stroke naturally detected in that linkage. Our results suggest that vitamins B6 and B9 could be beneficial for preventive therapy of stroke.


REFERENCES

  1. Lenzi GL, Franckowiak RSJ, Jones T. Cerebral oxygen metabolism and blood flow in human cerebral ischemic infarction. J Cereb Blood Flow Metab 1982; 2:321-35.

  2. Gibbs JM, Frackowiak RSJ, Legg NJ. Regional cerebral blood flow and oxygen metabolism in dementia due to vascular disease. Gerontology 1986; (suppl1) 32: 84-88.

  3. Williams GR, Jiang JG, Matchan DB, Samsa GP. Incidence and occurrence of total (first- ever and recurrent) stroke. Stroke 1999; 30: 2523-8.

  4. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21: 2-14.

  5. Chan PH. Oxygen radicals in focal cerebral ischemia. Brain Pathol 1994; 4: 59-65.

  6. Choi DW. Calcium- mediated neurotoxicity: relationship to specifie channel types and role in ischemic damage. Trends Neurosci 1988; 11: 465-9.

  7. Bulkley GB. Free radical mediated reperfusion injury. A selective review. Br J Cancer 1987; 55 (Suppl VIII): 66-73.

  8. Tanne D, Haim M, Goldbourt U. Prospective study of serum homocysteine and risk of ischemic stroke among patients with preexisting coronary heart disease. Stroke 2003; 34: 632-6.

  9. Homocysteine studies collaboration. Homocysteine and risk of ischemic heart disease and stroke: a metanalysis. JAMA 2002; 288: 2015-22.

  10. Sutton–Tyrrell K, Boston A, Selhub J, Zeigler–Johnson C. High homocysteine levels are independently related to isolated systolic hypertension in older adults. Circulation 1997; 96: 1745-9.

  11. Fiorina P, Lanfredini M, Montanari A. Plasma homocysteine and folate are related to arterial blood pressure in type 2 diabetes mellitus. Am J Hypertens 1998; 11: 1100-7

  12. Stehouwer CD, van Guldener C. Does homocysteine cause hypertension? Clin Chem Lab Med 2003; 41(11):1408-11.

  13. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arterioslerosis. Am J Pathol 1969; 56: 111-28.

  14. Welch GN, Upchurch G Jr, Loscalzo J. Hyperhomocy-st(e)ine-mia and atherotrombosis. Ann N Y Acad Sci. 1997; 811: 48-58.

  15. Farace FM, Lentz SR. Hyperhomocysteinemia, oxidative stress and cerebrovascular dysfunction. Stroke 2004; 35: 345-7.

  16. Cuskelly GJ, Stacpoole PW, Williamson J, Baumartner TG, Gregory JF. Deficiencies of folate and vitamin B6 exert distinct effects on homocysteine, serine and methionine kinetics. Am J Physiol Endocrinol Metab 2001; 281(6): E1182-90.

  17. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease: European COMAC Group. Circulation.1998; 97: 437-43.

  18. Teixeira F, Mizurinni D, Vianna LM. Pyridoxine and folic acid combined therapy provides the best fisiologic response. Ann Nutrition Metabolism 2003;47: 563-4.

  19. Okamoto K, Y. Nagaoka A. Establishment of the stroke prone spontaneously hypertensive rat. Circulation Res 1974; 34-45: supl 1 143-53.

  20. Purcell, JE, Lenhardt, SC, White, RF, Schaeffer, T, Barone, FC, Chandra, S. Strain-dependent response to cerebral ischemic preconditioning: differences between spontaneously hyper-tensive and stroke prone spontaneously hypertensive rats. Neuroscience Letters. 2003; 339: 151-5.

  21. Yen CH, Lau YT. Vascular responses in male and female hypertensive rats with hyperhomocysteinemia. Hypertension 2002; 40: 322-8.

  22. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mole Cell Biochem 1999, 200: 155-62.

  23. Nakiba T, Cui Z, Masuda J. The stroke prone spontaneously Hypertensive Rat: How good is it as a model for cerebrovascular diseases. Cell Mol Neurobiol 2004, 24(5): 639-44.

  24. Vianna LM, Wandenboer H, Batista KM, Silva F, Mizurinni D. Toxicidade da piridoxina observada em SHR idosos. Rev Cient Cent Univ Barra Mansa–UBM, Barra Mansa 2001; 3(6): 34-9.




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