Scully Mary-Frances

Language: English
References: 10
Page: 309-312
PDF size: 167.68 Kb.

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Introduction Factor XIII is an unusual clotting factor for multiple reasons. First when the circulating zymogen is activated it becomes a transglutaminase and not a proteinase. Also unlike other coagulation factors, factor XIII circulates as a tetramer, consisting of two subunits A and two subunits B The part of the molecule which become activated includes the two A subunits and the B subunits are considered to be inhibitory, protective and possibly regulatory. In plasma the B subunits are present in excess and 50% circulate as a homodimer. Factor XIII subunit A is present intracellularly in platelets, monocytes and macrophages, also as a homodimer. Another unusual characteristic is that each subunit is coded for on a separate gene.

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