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Academia Mexicana de Neurología, A.C.

2016, Number 1

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Rev Mex Neuroci 2016; 17 (1)

Long-term neuropsychological effects in patients with Parkinson’s disease who have undergone unilateral pallidotomy

González-Osornio MG, Ostrosky-Shejet F, Sandoval-Olivares L, Santana-Vargas DA, Haro-Valencia R, Hernández-Montiel ASD, Bruggeman B, Jiménez-Ponce F

Language: English
References: 43
Page: 34-43
PDF size: 149.04 Kb.


ABSTRACT

Introduction: Unilateral posteroventral pallidotomy (UPVP) has proven an effective treatment of motor symptoms in patients with advanced stages of Parkinson’s disease (PD), however, the cognitive effects have not been clearly defined.
Objective: The aim of this study was to assess the clinical outcome of UPVP and its neuropsychological effects.
Methods: For this study we studied 10 subjects with advanced PD who underwent UPVP and 10 subjects with advanced PD who were candidates for surgery but did not undergo the surgery (control), with the follow administered tests mini-mental Parkinson (MMP), NEUROPSI, Beck depression inventory (BDI), beck anxiety inventory (BAI), and a statistical analyses with a Wilcoxon rank-sum test compared the pre-operative and 12-month values and their changes across patients and between groups.
Results: Neuropsychological testing revealed declines in visual detection but improvements on 20-minute delayed verbal recall at 12-month follow-up from UPVP.
Conclusions: Visual disorders could be related to affections of the pathway between the thalamus and posterior parietal cortical areas. The increase in delayed recall could be associated with an increased L-dopa effect from the basal ganglia to the prefrontal dorsolateral cortex related with UPVP.


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