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ISSN 1561-3119 (Electronic)

2016, Number 2

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Rev Cubana Pediatr 2016; 88 (2)

Use of radiotherapy in treating central nervous system tumors of children and adolescents

Alert SJ, Chon RI, Ropero TR

Language: Spanish
References: 35
Page: 120-129
PDF size: 286.37 Kb.


ABSTRACT

Introduction: central nervous system tumors of children and adolescents are the most frequent location of neoplasias in Cuba, their treatment involves surgery followed by radiation in most cases, and chemotherapy or monoclonal antibodies in some histological types of tumors.
Objective: to evaluate the use of radiotherapy in treating central nervous system tumors of children and adolescents.
Methods: a series of 98 children and adolescents aged 3 to 18 years were treated with radiation at the National Institute of Oncology and Radiobiology including 32 brainstem tumors (32.6%), 19 medulloblastomas (19.4%), 11 grade I-II astrocytomas (11,2%), 9 grade III-IV astrocytomas and multiform glioblastomas (high grade gliomas, 9.2%), 6 craniopharyngiomas (6.1%), 6 primitive neuroectodermal tumors (6.1%), 5 oligodendrogliomas (5.1%), 4 ependymonas (4.1%), 3 germinomas (3.1%), 2 pineoblastomas (2.1%) and one case of gliomatosis (1%). The patients were irradiated with linear accelerators, thermoplastic masks of immobilization, conformal 3D planning or modulated intensity, dosimetric and imaging controls whereas anesthesia was used in infants.
Results: forty seven patients survived (47.9%) with a survival rate of 5 years (50.2%) and a median of 5.34 years.
Conclusions: radiation therapy proves to be an effective therapeutic tool for the treatment of central nervous tumors in children and adolescents.


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