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2016, Number 2

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Rev Cubana Invest Bioméd 2016; 35 (2)

Molecular mechanisms of obesity and the role of adipokines in metabolic disease

Irecta NCA, Álvarez GGC

Language: Spanish
References: 40
Page: 174-183
PDF size: 526.76 Kb.


ABSTRACT

Obesity is a public health problem worldwide. It has been estimated that 52 % adults and 30 % children are overweight. Knowledge about the molecular mechanisms involved in obesity leads to a better understanding of related conditions such as hypertension, cardiometabolic disease, cerebrovascular events and insulin resistance. Molecular events affect the signals issued by insulin, allowing resistance. A sustained inflammatory state is induced which is typical of obese people, characterized by the formation of atheromatous plaques, stimulation of a sustained prothrombotic state, and the occurrence of ischemic events. In the context of these conditions, the study of adipokines such as leptin, adiponectin, tumor necrosis factor alpha, C-reactive protein, serves to reveal the links between obesity and chronic disease, besides being a useful object of study to enhance diagnostic usefulness.


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