Valencia DE, Clavijo RT, Hernández SA, Savigne GW

Language: Spanish
References: 30
Page: 89-97
PDF size: 116.05 Kb.

ABSTRACT

International literature describes the paranganglioma of the carotid body as a very rare neoplasia that originates in type I cells of the normal carotid glomus present in the bifurcation of the common carotid. It affects both sexes at a ratio of 3 to 1, being predominant in females with low malignancy potential. It has also been related to living in high places. Carotid ganglionic tumors are infrequent, so their presentation is significant. This is a 52 years-old Caucasian male patient, who noticed swellings at both sides of the neck. On the physical examination, pulsating tumors were detected in both sides of the neck with positive Fontaine's sign. The color Doppler ultrasound revealed the existence of hypervascularized masses at both sides of the neck, being the largest those located on the left side, which received afferents through the external carotid branches. Early diagnosis is of utmost importance and imaging is the method that makes it easier to detect this condition and that provides the most sensitive and specific diagnosis, thus leading to the detection of a tumor even before it becoming palpable. Surgical treatment is the therapy of choice with good results.

REFERENCES

1. Khan Q, Heath D, Smith P. Anatomical variations in human carotid bodies. J Clin Pathol. 1988;41:1196-9.

2. Heath D. The human carotid body in health and disease. J Pathol. 1991;164:1-8.

3. Erdogan BA, Bora F, Altin G, Paksoy. Our experience with carotid body paragangliomas. Prague Medical Report. 2012;113(4):262-70.

4. Hsin-Ju C, Chih-Hsun C, Po-Chin W. Color doppler sonography of the neck in a patient with bilateral carotid body tumors. J Med Ultrasound. 2009;17(2);114-9.

5. Lacomme Y, Pessey JJ. Les tumeurs du corpuscule carotidien. XVI e Congrès de la Société Française de Carcinologie Faciale. In: Thomassin JM, Deveze A, Marciano S, editors. Actualités de carcinologie-cervico-faciale. Les chémodectomes cervicocéphaliques. Paris: Masson; 1984. p. 70-4.

6. Amato B, Bianco T, Compagna R, Siano M, Esposito G, Buffone G, et al. Surgical resection of carotid body paragangliomas:10 years of experience. Am J Surg. 2014;207(2):293-8.

7. Hinerman RW, Mendenhall WM, Amdur RJ, Stringer SP, Antonelli PJ, Cassisi NJ. Definitive radiotherapy in the management of chemodectomas arising in the temporal bone, carotid body, and glomus vagale. Head Neck. 2001;23:363-71.

8. Makeieff M, Thariat J, Reyt E. Treatment of cervical paragangliomas. Eur Ann Otorhinolaryngol. 2012;129:308-14.

9. Power A, Bower T, Kasperbauer J. Impact of preoperative embolization on outcomes of carotid body tumor resections. J Vasc Surg. 2012;56(4):979-89.

10. Zidi A, Bouaziz N, Mnif N, Kribi L, Kara M. Carotid body tumors: contribution of the various imaging techniques. A report of six cases. J Radiol. 2000;81:953-7.

11. Kakkos S, Reddy D, Shepard A. Contemporary presentation and evolution of management of neck paragangliomas. J Vasc Surg. 2009;49;1365-73.

12. Collins N, Dietzek A. Contiguous bilateral head and neck paragangliomas in a carrier of the SDHB germ line mutation. J Vasc Surg. 2012;55:216-9.

13. Burnichon N, Abermil N, Buffet A. The genetics of paragangliomas. Eur Ann Otorhinolaryngol. 2012;129:315-8.

14. Kohn SJ, Raftery BK, Jewell RE. Familial carotid body tumors: A closer look. J Vasc Surg. 1999;29:649-53.

15. Patlola R, Ingraldi A, Walker C, Allie D, Khan I. Carotid body tumor. Internat J Cardiol. 2010;143(1):e7-e10.

16. Fruhmann J, Ceigi J, Konstantiniuk P. Paraganglioma of the carotid body: Treatment strategy and SDH-gene mutations. Eur J Vasc Endovasc Surg 2013;45(5):431-6.

17. Sethi R, Sethi R, Herr M. Malignancy head and neck paragangliomas: Treatment efficacy and prognostic indicators. Am J Otolaryngol. 2013;34:431-8.

18. Künzel J, Koch M, Brase C, Fietkau R, Iro H, Zenk J. Treatment of cervical paragangliomas: Is surgery the only way? Am J of Otolaryngol. 2014;35(2):186-91.

19. Collins N, Dietzek A. Contiguous bilateral head and neck paragangliomas in a carrier of the SDHB germ line mutation. J Vasc Surg. 2012;55:216-9.

20. Sniezek JC, Netterville JL, Sabri AN. Vagal paragangliomas in paragangliomas of the head and neck. Otolaryngol Clin North Am. 2001;925-39.

21. Lu S, Li W, Liu D. Carotid body tumor: Diagnosis and surgical treatment. Zhonghua er bi yan hou ke za zhi. 1994;29(4):240-2.

22. Brandon D, Lippert D, Geer C. Clinical, histopathologic, and radiographic indicators of malignancy in head and neck paragangliomas. Otolaryngology. 2010;143:531-7.

23. Mena J. Metachronou bilateral nonfunctional inter-carotid paraganglioma (carotid body tumor) and functional retroperitoneal paraganglioma: Report of a case and review of the literature. Surgery. 1993;114(11):107-11.

24. Rabl H. Diagnosis and treatment of carotid body tumors. Thoracic Cardiovasc Surg. 1993 Dec;41(6);340-3.

25. Janen CJ, Baatenburg de Jong JR, Schipper J, Van der Mey GLA, Van Gils PGA. Color Doppler imaging of paragangliomas in the neck. J Clin Ultrasound. 1997;25:481-5.

26. Van den Berg R, van Gils AP, Wasser MN. Imaging of head and neck paragangliomas with three-dimensional time-of-flight MR angiography. Am J Roentgenol. 1999;172:1667-73.

27. Power A, Bower T, Kasperbauer J. Impact of pre-operative embolization on outcomes of carotid body tumor resections. J Vasc Surg. 2012;56(4):979-89.

28. Liapis CD, Evangelidakis EL, Papavassiliou VG. Role of malignancy and preoperative embolization in the management of carotid body tumors. World J Surg. 2000;24:1526-30.

29. Arslan H, Unal O, Kutluhan A, Sakarya ME. Power Doppler scanning in the diagnosis of carotid body tumors. J Ultrasound Med. 2000;19:367-70.

30. World Health Organization (WHO). Classification of tumours. In: Barnes L, Eveson J, Reichart W, editors. Pathology and genetics head and neck tumors. Lyon: IARC Press; 2005. p. 364-6.