Alonso RA, Pardo MD, Zabala EBT, Barrueta TS, Albelo AO

Language: Spanish
References: 34
Page: 204-212
PDF size: 321.65 Kb.

ABSTRACT

At present, the mechanisms involved in the "decision" of the immune system to promote an essentially effector response or a tolerant response are not fully known. Throughout history, immunological thinking has changed as the available technologies have led to a better understanding of the immune system. For these reasons, the present literature review was conducted to summarize the changes in immunological thinking regarding the fundamental problem of immunology. The concept of horror autotoxicus proposed by Erlich and the meaning of the clonal selection theory for understanding central tolerance were discussed. The two-signal model, Jerne’s contributions and his immune network theory were also addressed. Finally, the danger model and the theory of dominant tolerance were analyzed. The contributions of each theory to understanding how the immune system works were included.

REFERENCES

1. Paul WE. The Inmune System. In: Fundamental Immunology. 7th. ed. Philadelphia: Wolters Kluwer Health. Lippincott Williams & Wilkins; 2013. p. 234-46.

2. Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Frew AJ, Weyand CM. Clinical Inmunology. Principles and Practice. London: Mosby; 2008.

3. Rojas W, Anaya JM, Arisatizabal B, Cano LE, Gómez LM, Lopera D. Inmunología de Rojas. 16 ed. Medellín: Corporación para Investigaciones Biológicas; 2012.

4. Abbas AK, Lichtman AH, Pillai S. Celular and Molecular Inmunology. 7th. ed. Philadelphia: Elsevier; 2012.

5. Ehrlich P. Horror autotoxicus: the concept of autoinmunity. In: Silverstein AM. A History of Immunology. London: Elsevier; 2009. p. 153-76.

6. Jerne N. Theories of antibody formation. In: Silverstein AM. A History of Immunology. London: Elsevier; 2009. p. 44-65.

7. Forsdyke DR. The origins of the clonal selection theory of immunity as a case study for evaluation in science. The FASEB Journal. 1995 ; 23: 164-2.

8. Silverstein AM. The Clonal Selections Theory: what it really is and why modern challenges are misplace. Nature. 2002 ; 3 (9): 793-96.

9. Burnet F. The Clonal Selections Theory of Acquired Inmunity. Nashville: Vanderbilt University Press; 1959.

10. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foriegn cell. Nature. 1953 ; 172 (4379): 603-6.

11. Owen RD. Inmunogenetic consecuences of vascular anastomoses between bovine twins. Science. 1945 ; 102: 400-1.

12. Kappler JW, Staerz U, White J, Marrack PC. Self-tolerance eliminates T cell specific for Mls-modified products of major histocompatibility complex. Nature. 1988 ; 332 (6159): 35-40.

13. Simpson J, Hines P. Self-Discrimination, a Life and Death Issue. Science. 2002 ; 296: 297.

14. Burnet F. La Teoría de la Selección Clonal. Cambrige: Cambridge University Press; 1905.

15. Burnet F. Self and Notself: cellular immunology. Cambrige: Cambridge University Press; 1968.

16. Boehm T. Quality Control in Self/Nonself Discrimination. Cell. 2006 ; 125: 845-58.

17. Bretscher P. Living with the ups and downs of the two signal model. Immunol Cell Biol. 2004 ; 82 (2): 141-8.

18. Cohn M. Thoughts engendered by Bretscher´s Two-Step, Two-signal model for a peripheral self-non-self discrimination and the origin of primer effector T helpers. Scand J Immunol. 2015 ; 81 (2): 87-95.

19. Poskitt DC, Jean-Francois MJ, Turnbull S, Macdonald L, Yasmeen D. The nature of immunoglobulin idiotypes and idiotype-anti-idiotype interactions in immunological networks. Inmunol and Cel Biol. 1991 ; 69: 61-70.

20. Cohen IR, Young DB. Autoimmunity, microbial immunity and the immunological homunculos. Immunol Today. 1991 ; 12 (4): 105-10.

21. Blass S, Engel JM, Burmester GR. The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and therapeutic consequences. Z Rheumatol. 2001 ; 60 (1): 1-16.

22. González G, Montero E, León K, Cohen IR, Lage A. Autoimmunization to epidermal growth factor, a component of the immunological homunculus. Autoimmun Rev. 2002 ; 1 (1-2): 89-95.

23. Matzinger P. The Danger Model: A Renewed Sense of Self. Science. 2002 ; 296: 301-4.

24. Lotze MT, Zeh HJ, Rubartelli A, Sparvero LJ, Amoscato AA, Washburn NR, et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunological Reviews. 2007 ; 220: 60-81.

25. Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol. 2007 ; 81 (1): 1-5.

26. Probst H, Muth S, Schild H. Regulation of the tolerogenic function of steady-state DCs. Eur J Immunol. 2014 ; 44 (4): 927-33.

27. Pulendran B, Tang H, Manicassamy S. Programming dendritic cells to induce TH2 and tolerogenic responses. Nat Immunol. 2010 ; 11 (8): 647-55.

28. Zanoni I, Granucci F. The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance. Autoimmunity. 2011 ; 44 (1): 23-32.

29. Tisch R. Immunogenic versus tolerogenic dendritic cells: a matter of maturation. Int Rev Immunol. 2010 ; 29 (2): 111-8.

30. Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses?. Int Immunol. 2009 ; 21 (10): 1105-11.

31. Barnes MJ, Powrie F. Hybrid Treg cells: steel frames and plastic exteriors. Nat Immunol. 2009 ; 10 (6): 563-4.

32. Kornete M, Piccirillo C. Functional crosstalk between dendritic cells and Foxp3 regulatory T cells in the maintenance of immune tolerance. Front Inmunol. 2012 ; 3: 165.

33. Coquerelle C, Moser M. DC subsets in positive and negative regulation of immunity. Immunol Rev. 2010 ; 234 (1): 317-34.

34. Mayer CT, Berod L, Sparwasser T. Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Inmunol. 2012 ; 3: 183.