Evaluation of antimicrobial and modulatory activity of the ethanol extract of Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz

João Victor de Alencar Ferreira; Luciene Ferreira de Lima; Fernando Gomes Figueredo; Edinardo Fagner Ferreira Matias; Elba Sobral de Souza; Jacqueline Cosmo Andrade; Saulo Relison Tintino; Nadghia Figueiredo Leite; Rosimeire Sabino Albuquerque; Maria Flaviana Bezerra Morais Braga; Francisco Assis Bezerra da Cunha; José Galberto Martins da Costa; Henrique Douglas Melo Coutinho

2016, Number 1

Rev Cubana Plant Med 2016; 21 (1)

**Evaluation of antimicrobial and modulatory activity of the ethanol extract of Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz**

de Alencar FJV, Ferreira LL, Gomes FF, Ferreira MEF, Sobral SE, Cosmo AJ, Tintino SR, Figueiredo LN, Sabino AR, Bezerra MBMF, Bezerra CFA, Martins CJG, Melo CHD

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ABSTRACT

Introduction: Staphylococcus aureus is mentioned in the literature as an important pathogen, some opportunistic bacteria may cause several problems in many animals and humans. Escherichia coli is a leading cause of human infectious diseases. Belonging to the family Enterobacteriaceae, share many virulence factors described by their resistance to multiple antibiotics, the contamination is probably initiated by modifications in the host defenses. Pseudomonas aeruginosa is known to cause acute infection by producing toxins.
Objective: evaluate the antimicrobial effect of the ethanol extract of Libidibia ferrea (Mart ex Tul.) LP Queiroz, and modulation of antibiotic activity.
Methods: L. ferrea was collected in the municipality of Penaforte, Ceará, Brazil. To obtain the extracts were collected bark and fruits, submerged in ethanol separately for 72 h, after this period, filtered and concentrated in a rotary vacuum condenser. Antimicrobial activity tests were performed and modulation of antimicrobial activity with standards and multiresistant strains of bacteria.
Results: the extract showed antibacterial activity when combined with some antibiotics against the assayed strains, demonstrating a modulatory potential.
Conclusion: therefore, it is suggested that L. ferrea extract can be used as a source of natural products in the antimicrobial therapy and in the combat bacterial multidrug resistance.

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