Miranda HJL, Fernández CL, Garzón CL, Gómez VN, Pérez EL

Language: Spanish
References: 7
Page: 74-80
PDF size: 149.32 Kb.

ABSTRACT

A 59 year-old male patient with a history of hypertension and regular consumption of sildenafil entered the service because of acute stroke and headache seizure. Physical examination detected left hemiplegia. By skull nuclear gadolinium magnetic resonance, an expansive lesion is observed which caught heterogeneously contrast. Possible diagnosis of high-grade brain glioma was raised. Right frontoparietal craniotomy was performed and a tumor lesion was not visualized. After ruling out the presence of high-grade glioma, the diagnosis of hemorrhagic venous infarction was assessed. CT angiography and clotting was made to rule out prothrombotic states to justify this disease entity. Special hematology studies were within normal values. The case was concluded as a venous sinus thrombosis associated with the use of sildenafil.

REFERENCES

1. Stevenazzi M, Díaz L. Trombosis venosa cerebral. Arch Med Interna. 2012;34(2):43-6.

2. Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med. 2005;352:1791-8.

3. Lussana F, Dentalli F, Ageno W, Kamphulsen PW. Venous thrombosis at unusual sites and the role of trhombophilia. Semin Thromb Haemost. 2007;33:582-7.

4. Martinelli I, De Stefano V. Rare thromboses of cerebral, splanchnic and upper extremity veins. A narrative review. Thromb Haemost. 2010;103(6):1136-44.

5. Ferro JM, Canhao P, Stam J, Bousser MG, Barinagarrementeria F. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35:664-70.

6. Velásquez López JG, Agudelo Restrepo CA, Yepes Gómez D, Uribe Trujillo CA. Infarto agudo de miocardio asociado al consumo de sildenafil. Aportación de caso y revisión de la literatura. Actas Urol Esp. 2007 Ene;31(1):2-3.

7. Rufa A, Cerase A, Monti L, Dotti MT, Giorgio A, Sicurreli F, et al. Recurrent venous thrombosis including cerebral venous sinus thrombosis in a patient taking sildenafil for erectile dysfunction. J Neurol Sci. 2007 Sep 15;260(1-2):293-5.