2016, Number 2
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Rev Cuba Endoc 2016; 27 (2)
Heart failure and diabetes mellitus found in hospitalized patients in “Comandante Manuel Fajardo” university hospital
Licea PME, Garabito BAM
Language: Spanish
References: 43
Page: 134-148
PDF size: 227.13 Kb.
ABSTRACT
Introduction: Diabetes mellitus is associated to higher incidence and prevalence of
heart failure.
Objective: To determine the frequency of diabetes mellitus or hyperglycemia in
hospitalized patients with heart failure, and its possible association with the
prognosis.
Methods: Correlational, cross-sectional and descriptive study which revised 510
medical histories of hospitalized patients for heart failure at “Comandante Manuel
Fajardo” university hospital from 2009 to 2013. The study groups were 1) no
history of known diabetes mellitus and all normal glycemic values during
hospitalization; 2) previous diagnosis of diabetes mellitus and 3) no history of type
2 diabetes mellitus, hyperglycemia at some moment of their hospitalization, with no
history of detected diabetes mellitus, and with all normal glycemia values during
hospitalization. The studied variables were age, sex, body mass index, alcohol
consumption, causes of heart failure, blood pressure and pulsating pressure,
coronary disease, personal history, complications of heart failure, length of stay at
hospital, evolution, cause of death, glycemia average during hospitalization, antihyperglycemic
therapy and treatment of heart failure.
Results: Fifty nine percent of patients presented with hyperglycemia, 35% had
diabetes and 24% had not. Females and ages over 74 years predominated. The
main cause of heart failure was ischemic cardiopathy, more significant in diabetics
(p= 0.005). The main complications were bronchopneumonia and arrhythmias. The
conventional insulin was used by 73.33% of patients and the intensive one by
26.67%. Mortality rate was low. The possibility of dying was two times higher in
diabetics than in normoglycemic patients (OR= 2.01; CI 95 % 1.07-3.77; p= 0.03).
Conclusions: Hyperglycemia is frequent in hospitalized patients for heart failure; it
is associated to feminine sex, to ages older than 74 years, and complications. The
diabetic patients had double risk of dying if compared with patients with normal
glycemia values.
REFERENCES
American Diabetes Association. Standards of Medical Care in Diabetes-2013. Diabetes Care. 2013;36:S11-S59.
Licea ME, Valdés I, Fernández I, Armas NB. Valor pronóstico de la glucemia al ingreso hospitalario en personas con infarto agudo de miocardio. Rev Asociación Latinoamer Diabetes. 2012;20:249-59.
Valdés I, Licea ME, Armas NB. Valor pronóstico de la primera glucemia en ayunas al ingreso hospitalario en personas con infarto agudo de miocardio. Rev Cubana Hig Epidemiol [serie en Internet]. 2013 [citado 17 de diciembre de 2014];51(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 30032013000200003&lng=es&nrm=iso&tlng=es
Van Melle JP, Bot M, de Jonge P, de Boer RA, van Veldhuisen DJ, Whooley MA. Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the Heart and Soul Study. Diabetes Care. 2010;33:2084-9.
Lewis EF, Solomon SD, Jablonski KA, Rice MM, Clemenza F, Hsia J, et al; PEACE Investigators. Predictors of heart failure in patients with stable coronary artery disease: a PEACE study. Circ Heart Fail. 2009;2:209-16.
Litwin SE, Grossman W. Diabetic dysfunction as a cause of heart failure. J Am Coll Cardiol. 1993;22(4 Suppl A):49A-55A.
Rodríguez F, Guallar P, Banegas JR, Rey J. Trends in hospitalization and mortality for congestive heart failure in Spain, 1980-1993. Eur Heart J. 1997;18:1771-9.
Aldama G, López M, Piñeiro R, Campo R, Piñón P. Insuficiencia cardiaca: Concepto, epidemiología, clasificación, etiología y fisiopatología. Medicine. 2005;9:2279-90.
Dávila DF, Donis JH, González M, Sánchez F. Fisiopatología, diagnóstico y tratamiento médico de la insuficiencia cardiaca congestiva. Rev Venezolana Endocrinol Metab. 2010;8:88-94.
Trider P. Determination of glucose in blood using glucose-oxidase with alternative oxygen acceptor. Ann Clin Biochem. 1969;6:24-7.
World Health Organization. Obesity: preventing and management the global epidemic. Report of a WHO Technical Report Service; 2000. p. 1-253.
Batista ME, Licea ME. Corazón y diabetes mellitus. Enfermedad muscular cardiaca. Endocrinol Nutr. 1999;46:43-9.
The Seventh Report of the Joint National Committee on Prevention, Detection and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-25.
Sharpe N, Doughty R. Epidemiology of heart failure and ventricular dysfunction. Lancet. 1998;352(suppl 1):3.
Rodríguez JA, Garrido IP, Herminda LF, Castro A. Insuficiencia cardiaca crónica. Etiología, manifestaciones clínicas y criterios diagnósticos. Medicine. 2005;9:2300-7.
Aroor AR, Mandavia ChH, Sowers JR. Insulin resistance and heart failure: Molecular mechanisms. Heart Fail Clin. 2012;8:609-17.
Van der Horst IC, de Boer RA, Hillege HL, Boomsma F, Voors AA, van Veldhuisen DJ. Neurohormonal profile of patients with heart failure and diabetes. Neth Heart J. 2010 Apr;18(4):190-6.
Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone, et al; for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics. 2010 update: a report from the American Heart Association. Circulation. 2010;121:e46-215.
Cruz J, Licea M. Glucosilación no enzimática y complicaciones crónicas de la diabetes mellitus. Rev Cubana Endocrinol [serie en Internet]. 2010 [citado 17 de diciembre de 2014];21(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 29532010000200008&lng=es&nrm=iso&tlng=es
Reaven GM. Insulin resistance: the link between obesity and cardiovascular disease. Med Clin North Am. 2011;95:875-92.
Horwich TB, Fonarow GC. Glucose, obesity, metabolic syndrome, and diabetes relevance o incidence of heart failure. J Am Coll Cardiol. 2010;55:283-93.
Zhang Y, Ren J. ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. Pharmacol Ther. 2011;132:86-95.
Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, et al. P53-induced adipose tissue inflammation is critically evolved in the development of insulin resistance in heart failure. Cell Metabolism. 2012;15:51-64.
Licea ME, Singh O, Smith A, Martínez R. Frecuencia y características clínicas y resultados terapéuticos de la hipertensión arterial de diabéticos tipo 2 de un área de salud de la ciudad de La Habana. Rev Cubana Endocrinol. 2002;13:144-68.
Cruz Y, Licea ME, Hernández P, Llanes M, Santana A. Disfunción endotelial y diabetes mellitus. Rev Cubana Endocrinol. 2012;13:168-85.
Cruz J, Licea ME, Hernández P, Abraham EA, Yanes M. Estrés oxidativo y diabetes mellitus. Rev Mex Patol Clin. 2011;58:4-15.
Licea ME, Batista ME, Prohias JA, Seuc AC. Factores asociados a la disfunción ventricular izquierda sub-clínica en diabéticos tipo I. Av Diabetol. 1996;12:136-43.
Muraka S, Movahed MR. Diabetic cardiomyopathy. J Card Fail. 2010;16:971-9.
Peix A, Cabrera LO, Heres F, Rodríguez L, Valdes A, Valiente J, et al. Interrelation between myocardial perfusion imaging, coronary calcium score, and endothelial function in asymptomatic diabetics and controls. J Nucl Cardiol. 2011 Mar;18(3):393-5.
Baldasseroni S, Antenore A, Di Serio C, Orson F, Lonetto G, Bartola N, et al. Adiponectin, diabetes and ischemic heart failure: a challenging relationship. Cardiovasc Diabetol. 2012 Dic 18;11:151.
Kim JA, Jang HJ, Martínez-Lemus LA, Sowers JR. Activation of mTOR/p7056 kinase by ANG II inhibits its insulin-stimulated endothelial nitric oxide synthase and vasodilatation. Am J Physiol Endocrinol Metab. 2012 Jan;302(2):E201-E8.
Pulakat I, Aroor AR, Gul R, Sowers JR. Cardiac insulin resistance and microRNAmodulator. Exp Diabetes Res [serie en Internet]. 2012 [citado 10 de diciembre de 2015];2012:654904. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/21977024
Sowers JR. Role of TRIB3 in diabetic and over nutrition-induced atherosclerosis. Diabetes. 2012;61:265-6.
Whaley-Connell A, McCullough PA, Sowers JR. The role of oxidative stress in the metabolic syndrome. Rev Cardiovasc Med. 2011;12:21-9.
Castelo L, Licea ME. Dislipoproteinemia y diabetes mellitus. Rev Cubana Cardiol Cir Cardiovasc. 2010;16:140-55.
De Mora M, Pérez JM, Delgado JL, Urbano CA. Comorbilidad de los pacientes ingresados por insuficiencia cardiaca en un servicio de cardiología. Rev Esp Cardiol. 2011;64:75-83.
Singh O, Licea ME. Asociación de la nefropatía diabética incipiente con la presencia de disfunción ventricular izquierda en personas con diabetes tipo 1. Rev Asoc Latinoamer Diabetes. 2007;XV:190-2.
Givachini G, Cappagli M, Carros S, Borrini S, Montepagani A, Leoncini R, et al. Microalbuminuria predicts silent myocardial ischemia in type 2 diabetes patients. Eur J Nucl Mol Imaging. 20013;40:548-57.
Peix A. Usefulness of nuclear cardiology techniques for silent ischemic detection in diabetics. MEDICC Rev. 2013;15:33-6.
Aguilar D, Bozkurt B, Ramasubbu K, Deswal A. Relationship of Haemoglobin A1C and mortality in heart failure patients with Diabetes. Am Coll Cardiol. 2009;54:422-8.
Eshaghian S, Horwich TB, Fonarow GC. An unexpected inverse relationship between HbA1c levels and mortality in patients with diabetes and advanced systolic heart failure. Am Heart J. 2006;151:191-6.
Bautters C, Lamblind N, Mc Fadden EP, Van Belle E, Millaire A, de Groote P. Influence of diabetes mellitus on heart failure risk and outcomes. Cardiovac Diabetology. 2003;2:1-16.
Bota CE. Insuficiencia cardiaca y diabetes. Una combinación de alto riesgo. Rev Insuf Cardíaca. 2009;4:107-13.